The development of catalytic methodologies involving the formation of C–C bonds to enable
the generation of cyclic systems constitutes a field of great relevance in synthetic organic …

In recent years, many methods for the facile synthesis of pyridines and their derivatives have
been developed. The [2+ 2+ 2] cycloaddition reaction of alkynes and nitriles catalyzed by …

Abstract A metal‐free trimolecular [2+ 2+ 2] cycloaddition of internal ynamides and nitriles for
de novo synthesis of fully substituted pyridines is disclosed. With the versatile Brønsted acid …

The cyano moiety is a common and important functional group that exists in a myriad of
medicinal molecules and natural products. Moreover, nitriles serve as versatile precursors …

The application of alkyl and aryl substituted cyanamides in synthetic chemistry has
diversified multi-fold in recent years. In this review, we discuss recent advances (since 2012) …

The purpose of this review is to highlight ten years of success in the synthesis of six-
membered N-heterocycles using alkynes and nitrogen sources as substrates. It is our hope …

Transition metal-catalyzed [2+ 2+ 2] cycloadditions of nitrogen-linked 1, 6-diynes with
unsaturated motifs, such as alkynes, alkenes, nitriles, ketenes and isocyanates, have …

A rhodium/silver synergistic catalysis has been established, enabling cycloisomerization/
cross coupling of keto-vinylidenecyclopropanes (VDCPs) with terminal alkynes toward the …

A novel, efficient, and mild synthetic route for the preparation of 2-aminopyridines via
ruthenium-mediated [2+ 2+ 2] cycloaddition of α, ω-diynes and cyanamides has been …

Herein, we demonstrate the synthesis of azafluoranthene derivatives under mild conditions
via [2+ 2+ 2] cycloaddition of 1, 6‐diynes and nitriles catalyzed by CoBr2/dppp, exhibiting …