Adjuvantation of a SARS-CoV-2 mRNA vaccine with controlled tissue-specific expression of an mRNA encoding IL-12p70
Messenger RNA (mRNA) vaccines were pivotal in reducing severe acute respiratory
syndrome 2 (SARS-CoV-2) infection burden, yet they have not demonstrated robust …
syndrome 2 (SARS-CoV-2) infection burden, yet they have not demonstrated robust …
[HTML][HTML] Approaches to evaluate the specific immune responses to SARS-CoV-2
A Lopez-Gomez, HF Pelaez-Prestel, I Juarez - Vaccine, 2023 - Elsevier
The SARS-CoV-2 pandemic has a huge impact on public health and global economy,
meaning an enormous scientific, political, and social challenge. Studying how infection or …
meaning an enormous scientific, political, and social challenge. Studying how infection or …
Immunogenicity and protection of a variant nanoparticle vaccine that confers broad neutralization against SARS-CoV-2 variants
J Logue, RM Johnson, N Patel, B Zhou… - Nature …, 2023 - nature.com
SARS-CoV-2 variants have emerged with elevated transmission and a higher risk of
infection for vaccinated individuals. We demonstrate that a recombinant prefusion-stabilized …
infection for vaccinated individuals. We demonstrate that a recombinant prefusion-stabilized …
Mouse models of COVID-19 recapitulate inflammatory pathways rather than gene expression
How well mouse models recapitulate the transcriptional profiles seen in humans remains
debatable, with both conservation and diversity identified in various settings. Herein we use …
debatable, with both conservation and diversity identified in various settings. Herein we use …
Monoclonal antibodies specific for SARS-CoV-2 spike protein suitable for multiple applications for current variants of concern
The global coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has spawned an ongoing demand for …
respiratory syndrome coronavirus 2 (SARS-CoV-2) has spawned an ongoing demand for …
[HTML][HTML] Warmer ambient air temperatures reduce nasal turbinate and brain infection, but increase lung inflammation in the K18-hACE2 mouse model of COVID-19
Warmer climatic conditions have been associated with fewer COVID-19 cases. Herein we
infected K18-hACE2 mice housed at the standard animal house temperature of∼ 22° C, or …
infected K18-hACE2 mice housed at the standard animal house temperature of∼ 22° C, or …
The immunobiology of SARS-CoV-2 infection and vaccine responses: potential influences of cross-reactive memory responses and aging on efficacy and off-target …
CP Collins, DL Longo, WJ Murphy - Frontiers in Immunology, 2024 - frontiersin.org
Immune responses to both SARS-CoV-2 infection and its associated vaccines have been
highly variable within the general population. The increasing evidence of long-lasting …
highly variable within the general population. The increasing evidence of long-lasting …
Omicron XBB. 1.5 subvariant causes severe pulmonary disease in K18-hACE-2 mice
Owing to their continuous evolution, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) variants of concern (VOCs) display disparate pathogenicity in mouse models …
(SARS-CoV-2) variants of concern (VOCs) display disparate pathogenicity in mouse models …
[PDF][PDF] Craig P. Collins1, Dan L. Longo2 and William J. Murphy3
HH Nguyen, S Gunisetty, GT Barut, WJ Murphy - 2024 - scienceopen.com
Immune responses to both SARS-CoV-2 infection and its associated vaccines have been
highly variable within the general population. The increasing evidence of long-lasting …
highly variable within the general population. The increasing evidence of long-lasting …