Designer drugs: mechanism of action and adverse effects
D Luethi, ME Liechti - Archives of toxicology, 2020 - Springer
Psychoactive substances with chemical structures or pharmacological profiles that are
similar to traditional drugs of abuse continue to emerge on the recreational drug market …
similar to traditional drugs of abuse continue to emerge on the recreational drug market …
[HTML][HTML] Molecular and clinical aspects of potential neurotoxicity induced by new psychoactive stimulants and psychedelics
New psychoactive stimulants and psychedelics continue to play an important role on the
illicit new psychoactive substance (NPS) market. Designer stimulants and psychedelics both …
illicit new psychoactive substance (NPS) market. Designer stimulants and psychedelics both …
Ligand coupling mechanism of the human serotonin transporter differentiates substrates from inhibitors
The presynaptic serotonin transporter (SERT) clears extracellular serotonin following
vesicular release to ensure temporal and spatial regulation of serotonergic signalling and …
vesicular release to ensure temporal and spatial regulation of serotonergic signalling and …
Serotonin-releasing agents with reduced off-target effects
Increasing extracellular levels of serotonin (5-HT) in the brain ameliorates symptoms of
depression and anxiety-related disorders, eg, social phobias and post-traumatic stress …
depression and anxiety-related disorders, eg, social phobias and post-traumatic stress …
Allosteric modulation of neurotransmitter transporters as a therapeutic strategy
Neurotransmitter transporters (NTTs) are involved in the fine-tuning of brain neurotransmitter
homeostasis. As such, they are implicated in a plethora of complex behaviors, including …
homeostasis. As such, they are implicated in a plethora of complex behaviors, including …
Persistent binding at dopamine transporters determines sustained psychostimulant effects
Psychostimulants interacting with the dopamine transporter (DAT) can be used illicitly or for
the treatment of specific neuropsychiatric disorders. However, they can also produce severe …
the treatment of specific neuropsychiatric disorders. However, they can also produce severe …
Occlusion of the human serotonin transporter is mediated by serotonin-induced conformational changes in the bundle domain
The human serotonin transporter (hSERT) terminates neurotransmission by removing
serotonin (5HT) from the synaptic cleft, an essential process for proper functioning of …
serotonin (5HT) from the synaptic cleft, an essential process for proper functioning of …
Computational chemistry in structure-based solute carrier transporter drug design: Recent advances and future perspectives
G Tu, T Fu, G Zheng, B Xu, R Gou, D Luo… - Journal of chemical …, 2024 - ACS Publications
Solute carrier transporters (SLCs) are a class of important transmembrane proteins that are
involved in the transportation of diverse solute ions and small molecules into cells. There are …
involved in the transportation of diverse solute ions and small molecules into cells. There are …
Psychoactive drugs—from chemical structure to oxidative stress related to dopaminergic neurotransmission. A review
G Jîtcă, BE Ősz, A Tero-Vescan, CE Vari - Antioxidants, 2021 - mdpi.com
Nowadays, more and more young people want to experience illegal, psychoactive
substances, without knowing the risks of exposure. Besides affecting social life …
substances, without knowing the risks of exposure. Besides affecting social life …
[HTML][HTML] Role of amino terminal substitutions in the pharmacological, rewarding and psychostimulant profiles of novel synthetic cathinones
L Duart-Castells, N Nadal-Gratacós, M Muralter… - …, 2021 - Elsevier
The emergence of new synthetic cathinones continues to be a matter of public health
concern. In fact, they are quickly replaced by new structurally related alternatives. The main …
concern. In fact, they are quickly replaced by new structurally related alternatives. The main …