Tumour necrosis factor (TNF) is a major inflammatory cytokine that was first identified for its
ability to induce rapid haemorrhagic necrosis of experimental cancers. When efforts to …

Study objectives To review the concept of proinflammatory cytokines. Design Review of
published literature. Setting Academic (university hospital). Results Cytokines are regulators …

Abstract Tumour Necrosis Factor α (TNFα), is an inflammatory cytokine produced by
macrophages/monocytes during acute inflammation and is responsible for a diverse range …

Cytokines affect nearly every biological process; these include embryonic development,
disease pathogenesis, non‐specific response to infection, specific response to antigen …

The role of tumor necrosis factor (TNF) as an immune mediator has long been appreciated
but its function in the brain is still unclear. TNF receptor 1 (TNFR1) is expressed in most cell …

▪ Abstract Four members of the tumor necrosis factor (TNF) ligand family, TNF-α, LT-α, LT-β,
and LIGHT, interact with four receptors of the TNF/nerve growth factor family, the p55 TNF …

An interleukin-18 binding protein (IL-18BP) was purified from urine by chromatography on IL-
18 beads, sequenced, cloned, and expressed in COS7 cells. IL-18BP abolished IL-18 …

Background and Purpose Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine that
rapidly upregulates in the brain after injury. The present study was designed to explore the …

Abstract Tumor Necrosis Factor-alpha (TNF-α) is a prototypic pro-inflammatory cytokine
involved in the innate immune response. TNF-α ligation and downstream signaling with one …

Formerly called IFN-γ–inducing factor, IL-18 is the new name of a novel cytokine that plays
an important role in the TH1 response, primarily by its ability to induce IFN-γ production in T …