The global burden of respiratory diseases is very high and still on the rise, prompting the
need for accurate models for basic and translational research. Several model systems are …

Organoids have become a prominent model system in pulmonary research. The ability to
establish organoid cultures directly from patient tissue has expanded the repertoire of …

Using scRNA-seq and microscopy, we describe a cell that is enriched in the lower airways of
the developing human lung and identified by the unique coexpression of SCGB3A2/SFTPB …

The human respiratory system, consisting of the airway and alveoli, is one of the most
complex organs directly interfaced with the external environment. The diverse epithelial cells …

In vitro human models, such as gastruloids and organoids, are complex three-dimensional
(3D) structures often consist of cells from multiple germ layers that possess some attributes …

The objective of standard guideline for utilization of human lung organoids is to provide the
basic guidelines required for the manufacture, culture, and quality control of the lung …

Amidst the recent coronavirus disease 2019 (COVID-19) pandemic, respiratory system
research has made remarkable progress, particularly focusing on infectious diseases. Lung …

Lung diseases are one of the leading causes of global mortality. Advances in induced
pluripotent stem cell (iPSC) differentiation have enabled the creation of bronchiolar and …

Abstract Alveolar type 2 (AT2) cells function as stem cells in the adult lung and aid in repair
after injury. The current study aimed to understand the signaling events that control …

The lung is a vital organ that undergoes extensive morphological and functional changes
during postnatal development. To disambiguate how different cell populations contribute to …