Extraoral bitter taste receptors in health and disease
Bitter taste receptors (TAS2Rs or T2Rs) belong to the superfamily of seven-transmembrane
G protein–coupled receptors, which are the targets of> 50% of drugs currently on the market …
G protein–coupled receptors, which are the targets of> 50% of drugs currently on the market …
Clinical role of extraoral bitter taste receptors
J Jeruzal-Świątecka, W Fendler… - International Journal of …, 2020 - mdpi.com
Humans can recognise five basic tastes: sweet, sour, salty, bitter and umami. Sour and salty
substances are linked to ion channels, while sweet, bitter and umami flavours are …
substances are linked to ion channels, while sweet, bitter and umami flavours are …
The cellular and molecular basis of bitter tastant-induced bronchodilation
CH Zhang, LM Lifshitz, KF Uy, M Ikebe, KE Fogarty… - PLoS …, 2013 - journals.plos.org
Bronchodilators are a standard medicine for treating airway obstructive diseases, and β2
adrenergic receptor agonists have been the most commonly used bronchodilators since …
adrenergic receptor agonists have been the most commonly used bronchodilators since …
Extrasensory perception: odorant and taste receptors beyond the nose and mouth
G protein-coupled receptors (GPCRs) represent the largest family of transmembrane
receptors and are prime therapeutic targets. The odorant and taste receptors account for …
receptors and are prime therapeutic targets. The odorant and taste receptors account for …
Tas2R activation relaxes airway smooth muscle by release of Gαt targeting on AChR signaling
YW Zhou, J Sun, Y Wang, CP Chen… - Proceedings of the …, 2022 - National Acad Sciences
Both chronic obstructive pulmonary disease (COPD) and asthma are severe respiratory
diseases. Bitter receptor–mediated bronchodilation is a potential therapy for asthma, but the …
diseases. Bitter receptor–mediated bronchodilation is a potential therapy for asthma, but the …
The bitter truth about bitter taste receptors: beyond sensing bitter in the oral cavity
B Avau, I Depoortere - Acta physiologica, 2016 - Wiley Online Library
The bitter taste receptor (TAS 2R)‐family of G‐protein‐coupled receptors has been identified
on the tongue as detectors of bitter taste over a decade ago. In the last few years, they have …
on the tongue as detectors of bitter taste over a decade ago. In the last few years, they have …
The expression and relaxant effect of bitter taste receptors in human bronchi
S Grassin-Delyle, C Abrial, S Fayad-Kobeissi… - Respiratory …, 2013 - Springer
Background Bitter-taste receptors (TAS2Rs) have recently been involved in the relaxation of
mouse and guinea pig airways, and increased expression of TAS2Rs was shown in blood …
mouse and guinea pig airways, and increased expression of TAS2Rs was shown in blood …
Bitter tasting compounds dilate airways by inhibiting airway smooth muscle calcium oscillations and calcium sensitivity
X Tan, MJ Sanderson - British journal of pharmacology, 2014 - Wiley Online Library
Background and Purpose While selective, bitter tasting, TAS2R agonists can relax agonist‐
contracted airway smooth muscle (ASM), their mechanism of action is unclear. However …
contracted airway smooth muscle (ASM), their mechanism of action is unclear. However …
Bitter taste receptors for asthma therapeutics
AP Nayak, SD Shah, JV Michael… - Frontiers in …, 2019 - frontiersin.org
Clinical management of asthma and chronic obstructive pulmonary disease (COPD) has
primarily relied on the use of beta 2 adrenergic receptor agonists (bronchodilators) and …
primarily relied on the use of beta 2 adrenergic receptor agonists (bronchodilators) and …
The Transmembrane Protein 16A Ca2+-activated Cl− Channel in Airway Smooth Muscle Contributes to Airway Hyperresponsiveness
Rationale: Asthma is a chronic inflammatory disorder with a characteristic of airway
hyperresponsiveness (AHR). Ca2+-activated Cl−[Cl (Ca)] channels are inferred to be …
hyperresponsiveness (AHR). Ca2+-activated Cl−[Cl (Ca)] channels are inferred to be …