Exosomal delivery of therapeutic modulators through the blood–brain barrier; promise and pitfalls
M Heidarzadeh, Y Gürsoy-Özdemir, M Kaya… - Cell & Bioscience, 2021 - Springer
Nowadays, a large population around the world, especially the elderly, suffers from
neurological inflammatory and degenerative disorders/diseases. Current drug delivery …
neurological inflammatory and degenerative disorders/diseases. Current drug delivery …
Engineering nanosystems to overcome barriers to cancer diagnosis and treatment
Over the past two decades, multidisciplinary investigations into the development of
nanoparticles for medical applications have continually increased. However, nanoparticles …
nanoparticles for medical applications have continually increased. However, nanoparticles …
ApoE-targeting increases the transfer of solid lipid nanoparticles with donepezil cargo across a culture model of the blood–brain barrier
Pharmacological treatment of central nervous system (CNS) disorders is difficult, because
the blood–brain barrier (BBB) restricts the penetration of many drugs into the brain. To solve …
the blood–brain barrier (BBB) restricts the penetration of many drugs into the brain. To solve …
Glycocalyx regulates the strength and kinetics of cancer cell adhesion revealed by biophysical models based on high resolution label-free optical data
The glycocalyx is thought to perform a potent, but not yet defined function in cellular
adhesion and signaling. Since 95% of cancer cells have altered glycocalyx structure, this …
adhesion and signaling. Since 95% of cancer cells have altered glycocalyx structure, this …
Penetration of the SARS-CoV-2 spike protein across the blood–brain barrier, as revealed by a combination of a human cell culture model system and optical …
Since the outbreak of the global pandemic caused by severe acute respiratory coronavirus 2
(SARS-CoV-2), several clinical aspects of the disease have come into attention. Besides its …
(SARS-CoV-2), several clinical aspects of the disease have come into attention. Besides its …
Surface charge, glycocalyx, and blood-brain barrier function
The negative surface charge of brain microvessel endothelial cells is derived from the
special composition of their membrane lipids and the thick endothelial surface glycocalyx …
special composition of their membrane lipids and the thick endothelial surface glycocalyx …
Boosting the brain delivery of Atazanavir through nanostructured lipid carrier-based approach for mitigating neuroaids
Atazanavir (ATZ) presents poor brain availability when administered orally, which poses a
major hurdle in its use as an effective therapy for the management of NeuroAIDS. The …
major hurdle in its use as an effective therapy for the management of NeuroAIDS. The …
Mechanistic understanding from molecular dynamics in pharmaceutical research 2: lipid membrane in drug design
We review the use of molecular dynamics (MD) simulation as a drug design tool in the
context of the role that the lipid membrane can play in drug action, ie, the interaction …
context of the role that the lipid membrane can play in drug action, ie, the interaction …
Nanomedicine based strategies for oligonucleotide traversion across the blood–brain barrier
Neurological disorders are considered the most prominent cause of disability worldwide.
The major hurdle in the management of neurological disorders is the existence of the blood …
The major hurdle in the management of neurological disorders is the existence of the blood …
Flow induces barrier and glycocalyx-related genes and negative surface charge in a lab-on-a-chip human blood-brain barrier model
AR Santa-Maria, FR Walter… - Journal of Cerebral …, 2021 - journals.sagepub.com
Microfluidic lab-on-a-chip (LOC) devices allow the study of blood-brain barrier (BBB)
properties in dynamic conditions. We studied a BBB model, consisting of human endothelial …
properties in dynamic conditions. We studied a BBB model, consisting of human endothelial …