PPARγ Gene polymorphisms, metabolic disorders, and coronary artery disease

Y Song, S Li, C He - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Being activated by endogenous and exogenous ligands, nuclear receptor peroxisome
proliferator-activated receptor gamma (PPARγ) enhances insulin sensitivity, promotes …

Gene polymorphisms associated with non-alcoholic fatty liver disease and coronary artery disease: a concise review

XL Li, JQ Sui, LL Lu, NN Zhang, X Xu, QY Dong… - Lipids in health and …, 2016 - Springer
Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease which
represents a wide spectrum of hepatic damage. Several studies have reported that NAFLD …

Dissecting miRNA–gene networks to map clinical utility roads of pharmacogenomics-guided therapeutic decisions in cardiovascular precision medicine

F Chatzopoulou, KA Kyritsis, CI Papagiannopoulos… - Cells, 2022 - mdpi.com
MicroRNAs (miRNAs) create systems networks and gene-expression circuits through
molecular signaling and cell interactions that contribute to health imbalance and the …

PPARγ2 C1431T Polymorphism Interacts with the Antiobesogenic Effects of Kochujang, a Korean Fermented, Soybean-Based Red Pepper Paste, in Overweight …

Y Lee, YS Cha, Y Park, M Lee - Journal of Medicinal Food, 2017 - liebertpub.com
Kochujang, a Korean fermented soybean-based red pepper paste, has been reported to
have beneficial health effects. The aim of this study was to examine the antiobesity effects of …

Interaction between a variant of CDKN2A/B-gene with lifestyle factors in determining dyslipidemia and estimated cardiovascular risk: A step toward personalized …

M Mehramiz, F Ghasemi, H Esmaily, M Tayefi… - Clinical Nutrition, 2018 - Elsevier
Background & aims Several genome-wide-association-studies have identified genetic
variants in a region on chromosome 9p21 that are associated with an increased risk of …

Reduced serum levels of zinc and superoxide dismutase in obese individuals

K Torkanlou, B Bibak, A Abbaspour, H Abdi… - Annals of Nutrition and …, 2017 - karger.com
The oxidant-stress (OS) has an essential role to play in the pathogenesis and progression of
many diseases. OS is the outcome when the level of free-radical-formation is increased or …

Peroxisome Proliferator‐Activated Receptors Associated with Nonalcoholic Fatty Liver Disease

N Wang, R Kong, H Luo, X Xu, J Lu - PPAR research, 2017 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming a major cause of chronic liver
disease worldwide. Concurrent to an increase in NAFLD prevalence, there is an increase in …

Impact of cigarette smoking on serum pro-and anti-inflammatory cytokines and growth factors

MH Daloee, A Avan, SR Mirhafez… - American journal of …, 2017 - journals.sagepub.com
Inflammation plays a key role in the initiation, progression, and clinical manifestation of
atherosclerosis. Cigarette smoking is a risk factor for atherosclerosis and cardiovascular …

Serum vitamin E as a significant prognostic factor in patients with dyslipidemia disorders

M Barzegar-Amini, H Ghazizadeh… - Diabetes & Metabolic …, 2019 - Elsevier
Objectives Obesity and overweight are among the main causes of cardiovascular disease
(CVD) mortality. Dyslipidemia, fatty liver index, is strongly related to CVD. Vitamin E as an …

Is the mouse a good model of human PPARγ-related metabolic diseases?

A Pap, I Cuaranta-Monroy, M Peloquin… - International journal of …, 2016 - mdpi.com
With the increasing number of patients affected with metabolic diseases such as type 2
diabetes, obesity, atherosclerosis and insulin resistance, academic researchers and …