Proliferating cancer cells rely largely on glutamine for survival and proliferation. Glutamine
serves as a carbon source for the synthesis of lipids and metabolites via the TCA cycle, as …

Branched-chain amino acids (BCAAs) are critical for skeletal muscle and whole-body
anabolism and energy homeostasis. They also serve as signaling molecules, for example …

Hypoxia-inducible factors (HIFs) and the HIF-dependent cancer hallmarks angiogenesis and
metabolic rewiring are well-established drivers of breast cancer aggressiveness, therapy …

Breast cancer is a leading cause of death among women worldwide. Dysbiosis, an aberrant
composition of the microbiome, characterizes breast cancer. In this review we discuss the …

Despite the remarkable progress in cancer treatment up to now, we are still far from
conquering the disease. The most substantial change after the malignant transformation of …

Glutamine is a conditionally essential nutrient for many cancer cells, but it remains unclear
how consuming glutamine in excess of growth requirements confers greater fitness to …

The non-essential amino acid serine is a critical nutrient for cancer cells due to its diverse
biosynthetic functions. While some tumors can synthesize serine de novo, others are …

The neutral amino acid transporter solute carrier family 1 member 5 (SLC1A5 or ASCT2) is
overexpressed in many cancers. To identify its roles in tumors, we employed 143B …

Advances in cell metabolism over the past few decades have demonstrated glutamine as an
essential nutrient for cancer cell survival and proliferation. Glutamine offers a remarkable …

The synthesis of new amino acid-containing, cell-specific, therapeutically active polymers is
presented. Amino acids served as starting material for the preparation of tailored polymers …