Sphingolipids not only exert structural roles in cellular membranes, but also act as signaling
molecules in various physiological and pathological processes. A myriad of studies have …

One of the classic hallmarks of cancer is the imbalance between elevated cell proliferation
and reduced cell death. Ceramide, a bioactive sphingolipid that can regulate this balance …

Background Ferroptosis has been implicated in the pathological process of type 2 diabetic
osteoporosis (T2DOP), although the specific underlying mechanisms remain largely …

Metabolic pathways are complex and intertwined. Deficiencies in one or more enzymes in a
given pathway are directly linked with genetic diseases, most of them having devastating …

Simple Summary Sphingolipids, which are important cell membrane components, have
critical roles in regulating cancer cell signaling to control pro-tumoral or antitumoral …

Metabolic Reprogramming is a sign of tumor, and as one of the three major substances
metabolism, lipid has an obvious impact. Abnormal lipid metabolism is related to the …

Treatment of triple-negative breast cancer (TNBC) is challenging because of its “COLD”
tumor immunosuppressive microenvironment (TIME). Here, we present a hydrogel-mediated …

Invasive ductal carcinoma (IDC) is the most common histological subtype of malignant
breast cancer (BC), and accounts for 70–80% of all invasive BCs. IDC demonstrates great …

Background Ceramide, a bioactive signaling sphingolipid, has long been implicated in
cancer. Members of the ceramide synthase (CerS) family determine the acyl chain lengths of …

Breast cancer is the second leading cause of cancer-related death in women in the world,
and its management includes a combination of surgery, radiation therapy, chemotherapy …