[HTML][HTML] APOBECs and virus restriction
RS Harris, JP Dudley - Virology, 2015 - Elsevier
The APOBEC family of single-stranded DNA cytosine deaminases comprises a formidable
arm of the vertebrate innate immune system. Pre-vertebrates express a single APOBEC …
arm of the vertebrate innate immune system. Pre-vertebrates express a single APOBEC …
Animal models for HIV/AIDS research
T Hatziioannou, DT Evans - Nature Reviews Microbiology, 2012 - nature.com
The AIDS pandemic continues to present us with unique scientific and public health
challenges. Although the development of effective antiretroviral therapy has been a major …
challenges. Although the development of effective antiretroviral therapy has been a major …
Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1
JF Hultquist, JA Lengyel, EW Refsland… - Journal of …, 2011 - Am Soc Microbiol
Successful intracellular pathogens must evade or neutralize the innate immune defenses of
their host cells and render the cellular environment permissive for replication. For example …
their host cells and render the cellular environment permissive for replication. For example …
Antiretroelement activity of APOBEC3H was lost twice in recent human evolution
The primate APOBEC3 gene locus encodes a family of proteins (APOBEC3A-H) with various
antiviral and antiretroelement activities. Here, we trace the evolution of APOBEC3H activity …
antiviral and antiretroelement activities. Here, we trace the evolution of APOBEC3H activity …
The artiodactyl APOBEC3 innate immune repertoire shows evidence for a multi-functional domain organization that existed in the ancestor of placental mammals
Abstract Background APOBEC3 (A3) proteins deaminate DNA cytosines and block the
replication of retroviruses and retrotransposons. Each A3 gene encodes a protein with one …
replication of retroviruses and retrotransposons. Each A3 gene encodes a protein with one …
How host genetics dictates successful viral zoonosis
Viruses of wild and domestic animals can infect humans in a process called zoonosis, and
these events can give rise to explosive epidemics such as those caused by the HIV and …
these events can give rise to explosive epidemics such as those caused by the HIV and …
A macaque model of HIV-1 infection
T Hatziioannou, Z Ambrose… - Proceedings of the …, 2009 - National Acad Sciences
The lack of a primate model that utilizes HIV-1 as the challenge virus is an impediment to
AIDS research; existing models generally employ simian viruses that are divergent from HIV …
AIDS research; existing models generally employ simian viruses that are divergent from HIV …
Human immunodeficiency virus, restriction factors, and interferon
S Neil, P Bieniasz - Journal of Interferon & Cytokine Research, 2009 - liebertpub.com
Recent discoveries have revealed previously unappreciated complexity with which
retroviruses interact with their hosts. In particular, we have become aware that many …
retroviruses interact with their hosts. In particular, we have become aware that many …
Natural polymorphisms in human APOBEC3H and HIV-1 Vif combine in primary T lymphocytes to affect viral G-to-A mutation levels and infectivity
The Vif protein of HIV-1 allows virus replication by degrading several members of the host-
encoded APOBEC3 family of DNA cytosine deaminases. Polymorphisms in both host …
encoded APOBEC3 family of DNA cytosine deaminases. Polymorphisms in both host …
Endogenous origins of HIV-1 G-to-A hypermutation and restriction in the nonpermissive T cell line CEM2n
The DNA deaminase APOBEC3G converts cytosines to uracils in retroviral cDNA, which are
immortalized as genomic strand G-to-A hypermutations by reverse transcription. A single …
immortalized as genomic strand G-to-A hypermutations by reverse transcription. A single …