Synthetic molecular evolution of antimicrobial peptides

CH Chen, T Bepler, K Pepper, D Fu, TK Lu - Current opinion in …, 2022 - Elsevier
Highlights•Various peptide design methods have facilitated peptide–drug
development.•Only a few peptide therapeutics have entered the antibiotic market in the past …

No country for old antibiotics! Antimicrobial peptides (AMPs) as next-generation treatment for skin and soft tissue infection

M Răileanu, R Borlan, A Campu, L Janosi… - International Journal of …, 2023 - Elsevier
In recent years, the unprecedented rise of bacterial antibiotic resistance together with the
lack of adequate therapies have made the treatment of skin infections and chronic wounds …

Mechanistic understanding from molecular dynamics in pharmaceutical research 2: lipid membrane in drug design

T Róg, M Girych, A Bunker - Pharmaceuticals, 2021 - mdpi.com
We review the use of molecular dynamics (MD) simulation as a drug design tool in the
context of the role that the lipid membrane can play in drug action, ie, the interaction …

Nanoparticles functionalized ceramic membranes: fabrication, surface modification, and performance

D Ewis, NA Ismail, MA Hafiz, A Benamor… - … Science and Pollution …, 2021 - Springer
Membrane technologies are used intensively for desalination and wastewater treatment.
Water filtration using ceramic membranes exhibited high performance compared with …

Molecular dynamics for antimicrobial peptide discovery

N Palmer, JRMA Maasch, MDT Torres… - Infection and …, 2021 - Am Soc Microbiol
Although antimicrobial resistance is an increasingly significant public health concern, there
have only been two new classes of antibiotics approved for human use since the 1960s …

Aggregation and its influence on the bioactivities of a novel antimicrobial peptide, temporin-PF, and its analogues

Y Zai, X Xi, Z Ye, C Ma, M Zhou, X Chen… - International journal of …, 2021 - mdpi.com
Temporin is an antimicrobial peptide (AMP) family discovered in the skin secretion of ranid
frog that has become a promising alternative for conventional antibiotic therapy. Herein, a …

[HTML][HTML] Natural-product-based, carrier-free, noncovalent nanoparticles for tumor chemo-photodynamic combination therapy

Z Wang, L Yang - Pharmacological Research, 2024 - Elsevier
Cancer, with its diversity, heterogeneity, and complexity, is a significant contributor to global
morbidity, disability, and mortality, highlighting the necessity for transformative treatment …

Serotonin alters the phase equilibrium of a ternary mixture of phospholipids and cholesterol

O Engberg, A Bochicchio, AF Brandner… - Frontiers in …, 2020 - frontiersin.org
Unsaturated and saturated phospholipids tend to laterally segregate, especially in the
presence of cholesterol. Small molecules such as neurotransmitters, toxins, drugs etc …

Cannabidiol protects mouse hippocampal neurons from neurotoxicity induced by amyloid β-peptide25–35

KCB Salgado, RG de Freitas Nascimento… - Toxicology in Vitro, 2024 - Elsevier
Abstract Alzheimer's disease (AD), the most prevalent form of dementia worldwide, is a
significant health concern, according to the World Health Organization (WHO). The …

The antibiotic peptide daptomycin functions by reorganizing the membrane

A Pokorny, PF Almeida - The Journal of Membrane Biology, 2021 - Springer
The mechanism of the antimicrobial peptide daptomycin is reviewed and discussed.
Daptomycin is a last-resort antibiotic in current use against drug-resistant bacterial …