Src family kinases as therapeutic targets in advanced solid tumors: what we have learned so far
S Martellucci, L Clementi, S Sabetta, V Mattei, L Botta… - Cancers, 2020 - mdpi.com
Src is the prototypal member of Src Family tyrosine Kinases (SFKs), a large non-receptor
kinase class that controls multiple signaling pathways in animal cells. SFKs activation is …
kinase class that controls multiple signaling pathways in animal cells. SFKs activation is …
Non-receptor protein tyrosine kinases signaling pathways in normal and cancer cells
Protein tyrosine kinases (PTKs) are enzymes that transfer phosphate groups to tyrosine
residues on protein substrates. Phosphorylation of proteins causes changes in their function …
residues on protein substrates. Phosphorylation of proteins causes changes in their function …
[PDF][PDF] Proteogenomic characterization of human early-onset gastric cancer
We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations.
Phosphoproteome data elucidated signaling pathways associated with somatic mutations …
Phosphoproteome data elucidated signaling pathways associated with somatic mutations …
Plasma miR-21, miR-155, miR-10b, and Let-7a as the potential biomarkers for the monitoring of breast cancer patients
There is a pressing need for further studies to categorize and validate circulating microRNAs
(miRs) in breast cancer patients that can be one of the novel strategies for cancer screening …
(miRs) in breast cancer patients that can be one of the novel strategies for cancer screening …
Subtypes of HPV-positive head and neck cancers are associated with HPV characteristics, copy number alterations, PIK3CA mutation, and pathway signatures
Purpose: There is substantial heterogeneity within human papillomavirus (HPV)-associated
head and neck cancer (HNC) tumors that predispose them to different outcomes; however …
head and neck cancer (HNC) tumors that predispose them to different outcomes; however …
S100A8/S100A9 cytokine acts as a transcriptional coactivator during breast cellular transformation
Cytokines are extracellular proteins that convey messages between cells by interacting with
cognate receptors at the cell surface and triggering signaling pathways that alter gene …
cognate receptors at the cell surface and triggering signaling pathways that alter gene …
The stromal loss of miR-4516 promotes the FOSL1-dependent proliferation and malignancy of triple negative breast cancer
JE Kim, BG Kim, Y Jang, S Kang, JH Lee, NH Cho - Cancer letters, 2020 - Elsevier
Stroma-derived exosomal microRNA (exomiR) contributes to tumor progression, however,
which remains poorly understood. In our study, we analyzed exomiRs from the cancer …
which remains poorly understood. In our study, we analyzed exomiRs from the cancer …
Modulation of age-and cancer-associated DNA methylation change in the healthy colon by aspirin and lifestyle
Background Aberrant DNA methylation in gene promoters is associated with aging and
cancer, but the circumstances determining methylation change are unknown. We …
cancer, but the circumstances determining methylation change are unknown. We …
Aberrant expression of cell cycle and material metabolism related genes contributes to hepatocellular carcinoma occurrence
H Yan, Z Li, Q Shen, Q Wang, J Tian, Q Jiang… - Pathology-Research and …, 2017 - Elsevier
This study aims to deepen our understanding of the molecular mechanism underlying the
occurrence of hepatocellular carcinoma (HCC). We first downloaded a gene expression …
occurrence of hepatocellular carcinoma (HCC). We first downloaded a gene expression …
Understanding the cellular roles of Fyn-related kinase (FRK): implications in cancer biology
The non-receptor tyrosine kinase Fyn-related kinase (FRK) is a member of the BRK family
kinases (BFKs) and is distantly related to the Src family kinases (SFKs). FRK was first …
kinases (BFKs) and is distantly related to the Src family kinases (SFKs). FRK was first …