Bilirubin is an endogenous compound that can be toxic under certain conditions but, on the
other hand, mild unconjugated hyperbilirubinaemia might protect against cardiovascular …

Drug lag, recently discussed extensively in Japan, can be divided into two phases: clinical
development time and application review time. The former factor is still an important problem …

Background Next-generation sequencing in cancer research may reveal germline variants
of clinical significance. We report patient preferences for return of results and the prevalence …

During the past two decades the first sequencing of the human genome was performed
showing its high degree of inter-individual differentiation, as a result of large international …

Purpose A comprehensive haplotype analysis of UGT1A1 in the Japanese population was
conducted, and the effects of these haplotypes were investigated with respect to UGT1A1 …

The anticancer agent irinotecan (CPT-11) is converted to SN-38, which is approximately 100
to 1000-fold more cytotoxic than the parent drug. The pharmacokinetics of irinotecan are …

The uridine diphosphoglucuronosyltransferases (UGTs) belong to a superfamily of enzymes
that catalyse the glucuronidation of numerous endobiotics and xenobiotics. Several human …

Abstract Irinotecan (CPT-11), a first-line chemotherapy for advanced colorectal cancer,
causes serious diarrhea in patients receiving treatment. The underlying mechanism has …

This review summarizes published in vitro, animal, and clinical studies investigating the
effects of green tea (Camellia sinensis) extract and associated catechins on drug …

BACKGROUND FOLFIRINOX and gemcitabine plus nab-paclitaxel (Gem+ nabPTX) were
recently introduced for metastatic pancreatic cancer treatment. However, studies that …