A new era of antibiotics: the clinical potential of antimicrobial peptides

K Browne, S Chakraborty, R Chen… - International journal of …, 2020 - mdpi.com
Antimicrobial resistance is a multifaceted crisis, imposing a serious threat to global health.
The traditional antibiotic pipeline has been exhausted, prompting research into alternate …

Antimicrobial peptides: Application informed by evolution

BP Lazzaro, M Zasloff, J Rolff - Science, 2020 - science.org
BACKGROUND Antimicrobial peptides (AMPs) are small proteins with potent antibacterial,
antiviral, and antifungal activity. AMPs are ubiquitous among multicellular eukaryotes, with …

Host control of the microbiome: mechanisms, evolution, and disease

J Wilde, E Slack, KR Foster - Science, 2024 - science.org
Many species, including humans, host communities of symbiotic microbes. There is a vast
literature on the ways these microbiomes affect hosts, but here we argue for an increased …

Host specificity of the gut microbiome

EK Mallott, KR Amato - Nature Reviews Microbiology, 2021 - nature.com
Developing general principles of host–microorganism interactions necessitates a robust
understanding of the eco-evolutionary processes that structure microbiota. Phylosymbiosis …

[HTML][HTML] Reassessing the host defense peptide landscape

EF Haney, SK Straus, REW Hancock - Frontiers in chemistry, 2019 - frontiersin.org
Current research has demonstrated that small cationic amphipathic peptides have strong
potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and …

Phylosymbiosis: relationships and functional effects of microbial communities across host evolutionary history

AW Brooks, KD Kohl, RM Brucker, EJ van Opstal… - PLoS …, 2016 - journals.plos.org
Phylosymbiosis was recently proposed to describe the eco-evolutionary pattern, whereby
the ecological relatedness of host-associated microbial communities parallels the phylogeny …

Interplay between innate immunity and the plant microbiota

S Hacquard, S Spaepen, R Garrido-Oter… - Annual review of …, 2017 - annualreviews.org
The innate immune system of plants recognizes microbial pathogens and terminates their
growth. However, recent findings suggest that at least one layer of this system is also …

Microbiota and host nutrition across plant and animal kingdoms

S Hacquard, R Garrido-Oter, A González, S Spaepen… - Cell host & …, 2015 - cell.com
Plants and animals each have evolved specialized organs dedicated to nutrient acquisition,
and these harbor specific bacterial communities that extend the host's metabolic repertoire …

Simple animal models for microbiome research

AE Douglas - Nature Reviews Microbiology, 2019 - nature.com
The health and fitness of animals, including humans, are influenced by the presence and
composition of resident microbial communities. The development of rational microbial …

Microbiota mediated plasticity promotes thermal adaptation in the sea anemone Nematostella vectensis

L Baldassarre, H Ying, AM Reitzel… - Nature …, 2022 - nature.com
At the current rate of climate change, it is unlikely that multicellular organisms will be able to
adapt to changing environmental conditions through genetic recombination and natural …