[HTML][HTML] Blood development: hematopoietic stem cell dependence and independence
E Dzierzak, A Bigas - Cell stem cell, 2018 - cell.com
Evidence of the diversity and multi-layered organization of the hematopoietic system is
leading to new insights that may inform ex vivo production of blood cells. Interestingly, not all …
leading to new insights that may inform ex vivo production of blood cells. Interestingly, not all …
Aging of hematopoietic stem cells
G de Haan, SS Lazare - Blood, The Journal of the American …, 2018 - ashpublications.org
Hematopoietic stem cells (HSCs) ensure a balanced production of all blood cells throughout
life. As they age, HSCs gradually lose their self-renewal and regenerative potential, whereas …
life. As they age, HSCs gradually lose their self-renewal and regenerative potential, whereas …
Haematopoietic stem and progenitor cells from human pluripotent stem cells
A variety of tissue lineages can be differentiated from pluripotent stem cells by mimicking
embryonic development through stepwise exposure to morphogens, or by conversion of one …
embryonic development through stepwise exposure to morphogens, or by conversion of one …
Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis
The dynamics of haematopoietic stem cell differentiation and the hierarchy of oligopotent
stem cells in the bone marrow remain controversial. Here we dissect haematopoietic …
stem cells in the bone marrow remain controversial. Here we dissect haematopoietic …
Transcriptional heterogeneity and lineage commitment in myeloid progenitors
Within the bone marrow, stem cells differentiate and give rise to diverse blood cell types and
functions. Currently, hematopoietic progenitors are defined using surface markers combined …
functions. Currently, hematopoietic progenitors are defined using surface markers combined …
Hematopoietic stem cell niche maintenance during homeostasis and regeneration
A Mendelson, PS Frenette - Nature medicine, 2014 - nature.com
The bone marrow niche has mystified scientists for many years, leading to widespread
investigation to shed light into its molecular and cellular composition. Considerable efforts …
investigation to shed light into its molecular and cellular composition. Considerable efforts …
Hematopoietic stem cells: concepts, definitions, and the new reality
CJ Eaves - Blood, The Journal of the American Society of …, 2015 - ashpublications.org
Hematopoietic stem cell (HSC) research took hold in the 1950s with the demonstration that
intravenously injected bone marrow cells can rescue irradiated mice from lethality by …
intravenously injected bone marrow cells can rescue irradiated mice from lethality by …
CellNet: network biology applied to stem cell engineering
Somatic cell reprogramming, directed differentiation of pluripotent stem cells, and direct
conversions between differentiated cell lineages represent powerful approaches to engineer …
conversions between differentiated cell lineages represent powerful approaches to engineer …
Tracing haematopoietic stem cell formation at single-cell resolution
Haematopoietic stem cells (HSCs) are derived early from embryonic precursors, such as
haemogenic endothelial cells and pre-haematopoietic stem cells (pre-HSCs), the molecular …
haemogenic endothelial cells and pre-haematopoietic stem cells (pre-HSCs), the molecular …
A circular RNA protects dormant hematopoietic stem cells from DNA sensor cGAS-mediated exhaustion
Disrupting the balance between self-renewal and differentiation of hematopoietic stem cells
(HSCs) leads to bone marrow failure or hematologic malignancy. However, how HSCs …
(HSCs) leads to bone marrow failure or hematologic malignancy. However, how HSCs …