The Genetic Basis for Cardiomyopathy: Cell Skip to Main Content Advertisement Cell This
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Cardiomyopathies are disorders affecting heart muscle that usually result in inadequate
pumping of the heart. They are the most common cause of heart failure and each year kill …

Dominant missense pathogenic variants in cardiac myosin heavy chain cause hypertrophic
cardiomyopathy (HCM), a currently incurable disorder that increases risk for stroke, heart …

Familial hypertrophic cardiomyopathy (HCM) is a prevalent hereditary cardiac disorder
linked to arrhythmia and sudden cardiac death. While the causes of HCM have been …

Inherited cardiomyopathies include hypertrophic cardiomyopathy, dilated cardiomyopathy,
arrhythmogenic right ventricular cardiomyopathy, left ventricular noncompaction, and …

Rationale: At birth, there is a switch from placental to pulmonary circulation and the heart
commences its aerobic metabolism. In cardiac myocytes, this transition is marked by …

Cardiomyopathies are diseases of heart muscle that may result from a diverse array of
conditions that damage the heart and other organs and impair myocardial function, including …

Dominant mutations in sarcomere protein genes cause hypertrophic cardiomyopathy, an
inherited human disorder with increased ventricular wall thickness, myocyte hypertrophy …

Loss of cardiomyocytes through programmed cell death is a key event in the development of
heart failure, but the inciting molecular mechanisms are largely unknown. We used …

Factors that render patients with cardiovascular disease at high risk for heart failure remain
incompletely defined. Recent insights into molecular genetic causes of myocardial diseases …