Education and cognitive functioning across the life span
Cognitive abilities are important predictors of educational and occupational performance,
socioeconomic attainment, health, and longevity. Declines in cognitive abilities are linked to …
socioeconomic attainment, health, and longevity. Declines in cognitive abilities are linked to …
The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer's disease
A Webers, MT Heneka… - Immunology and cell …, 2020 - Wiley Online Library
Alzheimer's disease (AD) is characterized by amyloid beta (Aβ) accumulation, tau pathology
and neuroinflammation. Recently, there has been considerable interest in the role of …
and neuroinflammation. Recently, there has been considerable interest in the role of …
Defeating Alzheimer's disease and other dementias: a priority for European science and society
Executive summary Alzheimer's disease (AD) is the leading cause of dementia, and
because the primary risk factor for AD is old age, the prevalence of the disease is increasing …
because the primary risk factor for AD is old age, the prevalence of the disease is increasing …
Astrocytes: a central element in neurological diseases
The neurone-centred view of the past disregarded or downplayed the role of astroglia as a
primary component in the pathogenesis of neurological diseases. As this concept is …
primary component in the pathogenesis of neurological diseases. As this concept is …
Cannabidiol for neurodegenerative disorders: A comprehensive review
Despite the significant advances in neurology, the cure for neurodegenerative conditions
remains a formidable task to date. Among various factors arising from the complex etiology …
remains a formidable task to date. Among various factors arising from the complex etiology …
Three dimensions of the amyloid hypothesis: time, space and'wingmen'
ES Musiek, DM Holtzman - Nature neuroscience, 2015 - nature.com
The amyloid hypothesis, which has been the predominant framework for research in
Alzheimer's disease (AD), has been the source of considerable controversy. The amyloid …
Alzheimer's disease (AD), has been the source of considerable controversy. The amyloid …
Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disease in which the
formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of …
formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of …
Rare-disease genetics in the era of next-generation sequencing: discovery to translation
Work over the past 25 years has resulted in the identification of genes responsible for~ 50%
of the estimated 7,000 rare monogenic diseases, and it is predicted that most of the …
of the estimated 7,000 rare monogenic diseases, and it is predicted that most of the …
[HTML][HTML] Molecular genetics of early-onset Alzheimer's disease revisited
R Cacace, K Sleegers, C Van Broeckhoven - Alzheimer's & dementia, 2016 - Elsevier
As the discovery of the Alzheimer's disease (AD) genes, APP, PSEN1, and PSEN2, in
families with autosomal dominant early-onset AD (EOAD), gene discovery in familial EOAD …
families with autosomal dominant early-onset AD (EOAD), gene discovery in familial EOAD …
Molecular basis of familial and sporadic Alzheimer's disease
J Dorszewska, M Prendecki… - Current Alzheimer …, 2016 - ingentaconnect.com
Alzheimer's disease (AD) is a multifactorial disease with genetic (70%) and environmental
(30%) causes. Among the genetic factors are genes associated with a family history of the …
(30%) causes. Among the genetic factors are genes associated with a family history of the …