Amyotrophic lateral sclerosis (ALS) is an idiopathic, fatal neurodegenerative disease of the
human motor system. In this Seminar, we summarise current concepts about the origin of the …

To date, pharmacological treatments for mood and anxiety disorders and for drug
dependence show limited efficacy, leaving a large number of patients suffering severe and …

Although nerve cell death is the hallmark of many neurological diseases, the processes
underlying this death are still poorly defined. However, there is a general consensus that …

Ferroptosis is an iron-and reactive oxygen species (ROS)-dependent form of regulated cell
death, that has been implicated in Alzheimer's disease and Parkinson's disease. Inhibition of …

ABSTRACT Hydrogen sulfide (H2S), which is a well‐known toxic gas, is found in relatively
high concentrations in the brain. Although a neuromodulatory role of H2S has been …

Flavonoids are a family of antioxidants found in fruits and vegetables as well as in popular
beverages such as red wine and tea. Although the physiological benefits of flavonoids have …

Background: Reactive oxygen species (ROS) may play a role in some neuropsychiatric
disorders. There is some evidence that the activation of immune-inflammatory process …

Reactive oxygen species (ROS) are thought to be involved in many forms of programmed
cell death. The role of ROS in cell death caused by oxidative glutamate toxicity was studied …

An early and highly specific decrease in glutathione (GSH) in the substantia nigra is
associated with Parkinson's disease, and low levels of GSH lead to the degeneration of …

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder of
the motor neurons in the motor cortex, brainstem and spinal cord. A combination of upper …