Metalloproteins and metal sensing

KJ Waldron, JC Rutherford, D Ford, NJ Robinson - Nature, 2009 - nature.com
Almost half of all enzymes must associate with a particular metal to function. An ambition is
to understand why each metal–protein partnership arose and how it is maintained. Metal …

Molecular mechanisms of copper uptake and distribution

S Puig, DJ Thiele - Current opinion in chemical biology, 2002 - Elsevier
In the past few years, exciting advances have been made toward understanding how copper
is transported into and distributed to cupro-proteins within cells. Recent work has identified …

Biochemical characterization of the human copper transporter Ctr1

J Lee, MMO Peña, Y Nose, DJ Thiele - Journal of Biological Chemistry, 2002 - ASBMB
The trace metal copper is an essential cofactor for a number of biological processes
including mitochondrial oxidative phosphorylation, free radical detoxification …

[HTML][HTML] Charting the travels of copper in eukaryotes from yeast to mammals

T Nevitt, H Öhrvik, DJ Thiele - … et Biophysica Acta (BBA)-Molecular Cell …, 2012 - Elsevier
Throughout evolution, all organisms have harnessed the redox properties of copper (Cu)
and iron (Fe) as a cofactor or structural determinant of proteins that perform critical functions …

Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development

J Lee, JR Prohaska, DJ Thiele - Proceedings of the …, 2001 - National Acad Sciences
The trace metal copper (Cu) plays an essential role in biology as a cofactor for many
enzymes that include Cu, Zn superoxide dismutase, cytochrome oxidase, ceruloplasmin …

Elemental economy: microbial strategies for optimizing growth in the face of nutrient limitation

SS Merchant, JD Helmann - Advances in microbial physiology, 2012 - Elsevier
Microorganisms play a dominant role in the biogeochemical cycling of nutrients. They are
rightly praised for their facility for fixing both carbon and nitrogen into organic matter, and …

Biochemical and genetic analyses of yeast and human high affinity copper transporters suggest a conserved mechanism for copper uptake

S Puig, J Lee, M Lau, DJ Thiele - Journal of Biological Chemistry, 2002 - ASBMB
The redox active metal copper is an essential cofactor in critical biological processes such
as respiration, iron transport, oxidative stress protection, hormone production, and …

Identification of a copper transporter family in Arabidopsis thaliana

V Sancenón, S Puig, H Mira, DJ Thiele… - Plant molecular …, 2003 - Springer
Despite copper ions being crucial in proteins participating in plant processes such as
electron transport, free-radical elimination and hormone perception and signaling, very little …

Iron acquisition and transcriptional regulation

CD Kaplan, J Kaplan - Chemical reviews, 2009 - ACS Publications
Iron is an essential element for all eukaryotes. The facile ability of iron to gain and lose
electrons permits its participation in a wide variety of oxidation-reduction reactions. Further …

Metal-responsive transcription factors that regulate iron, zinc, and copper homeostasis in eukaryotic cells

JC Rutherford, AJ Bird - Eukaryotic cell, 2004 - Am Soc Microbiol
Iron, copper, and zinc are all essential nutrients. The electron transfer properties of iron and
copper are fundamental to processes such as respiration and photosynthesis. Zinc forms the …