Scleral structure and biomechanics

C Boote, IA Sigal, R Grytz, Y Hua, TD Nguyen… - Progress in retinal and …, 2020 - Elsevier
As the eye's main load-bearing connective tissue, the sclera is centrally important to vision.
In addition to cooperatively maintaining refractive status with the cornea, the sclera must …

A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma

CF Burgoyne - Experimental eye research, 2011 - Elsevier
This article is dedicated to Rosario Hernandez for her warm support of my own work and her
genuine enthusiasm for the work of her colleagues throughout her career. I first met Rosario …

Biomechanics of the human posterior sclera: age-and glaucoma-related changes measured using inflation testing

B Coudrillier, J Tian, S Alexander… - … & visual science, 2012 - iovs.arvojournals.org
Purpose.: The objective of this study was to measure the biomechanical response of the
human posterior sclera in vitro and to estimate the effects of age and glaucoma. Methods …

Scleral thickness in human eyes

S Vurgese, S Panda-Jonas, JB Jonas - PloS one, 2012 - journals.plos.org
Purpose To obtain information about scleral thickness in different ocular regions and its
associations. Methods The histomorphometric study included 238 human globes which had …

Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy

RW Nickells, GR Howell, I Soto… - Annual review of …, 2012 - annualreviews.org
Glaucoma is a complex neurodegenerative disorder that is expected to affect 80 million
people by the end of this decade. Retinal ganglion cells (RGCs) are the most affected cell …

Biomechanics of the optic nerve head

IA Sigal, CR Ethier - Experimental eye research, 2009 - Elsevier
Biomechanical factors acting at the level of the lamina cribrosa (LC) are postulated to play a
role in retinal ganglion cell dysfunction and loss in glaucoma. In support of this postulate, we …

Aging and ocular tissue stiffness in glaucoma

B Liu, S McNally, JI Kilpatrick, SP Jarvis… - Survey of …, 2018 - Elsevier
Glaucoma is a progressive and chronic neurodegenerative disorder characterized by
damage to the inner layers of the retina and deformation of the optic nerve head. The …

Parapapillary atrophy: histological gamma zone and delta zone

JB Jonas, SB Jonas, RA Jonas, L Holbach, Y Dai… - 2012 - journals.plos.org
Background To examine histomorphometrically the parapapillary region in human eyes.
Methodology/Principal Findings The histomorphometric study included 65 human globes …

Glaucomatous cupping of the lamina cribrosa: a review of the evidence for active progressive remodeling as a mechanism

JC Downs, MD Roberts, IA Sigal - Experimental eye research, 2011 - Elsevier
The purpose of this review is to examine the literature in an attempt to elucidate a
biomechanical basis for glaucomatous cupping. In particular, this work focuses on the role of …

[HTML][HTML] Biomechanical changes in the sclera of monkey eyes exposed to chronic IOP elevations

MJA Girard, JKF Suh, M Bottlang… - … & visual science, 2011 - tvst.arvojournals.org
Purpose.: To characterize scleral biomechanics in both eyes of eight monkeys in which
chronic intraocular pressure (IOP) elevation was induced in one eye. Methods.: Each …