Owing to their ability to efficiently generate ATP required to sustain normal cell function,
mitochondria are often considered the 'powerhouses of the cell'. However, our …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Dynamic interactions between organelles are responsible for a variety of intercellular
functions, and the endoplasmic reticulum (ER)–mitochondrial axis is recognized as a …

Organelles form tight connections through membrane contact sites, thereby cooperating to
regulate homeostasis and cell function. Among them, the contact between endoplasmic …

Cancer immunotherapy is rapidly advancing in the treatment of a variety of hematopoietic
cancers, including pediatric acute lymphoblastic leukemia and diffuse large B cell …

The tight cross talk between two essential organelles of the cell, the endoplasmic reticulum
(ER) and mitochondria, is spatially and functionally regulated by specific microdomains …

Abnormal metabolism serves a critical role in the development and progression of different
types of malignancies including glioblastoma (GBM), and may therefore serve as a …

Mitochondria and endoplasmic reticulum (ER) contact sites (MERCs) are dynamic modules
enriched in subset of lipids and specialized proteins that determine their structure and …

The complex physiology of eukaryotic cells requires that a variety of subcellular organelles
perform unique tasks, even though they form highly dynamic communication networks. In the …

During metabolic reprogramming, glioma cells and their initiating cells efficiently utilized
carbohydrates, lipids and amino acids in the hypoxic lesions, which not only ensured …