Microneedle-based natural polysaccharide for drug delivery systems (DDS): progress and challenges

F Damiri, N Kommineni, SO Ebhodaghe, R Bulusu… - Pharmaceuticals, 2022 - mdpi.com
In this focused progress review, the most widely accepted methods of transdermal drug
delivery are hypodermic needles, transdermal patches and topical creams. However …

Biodegradable microneedles fabricated with carbohydrates and proteins: Revolutionary approach for transdermal drug delivery

N Dabholkar, S Gorantla, T Waghule, VK Rapalli… - International Journal of …, 2021 - Elsevier
There has been a surge in the use of transdermal drug delivery systems (TDDS) for the past
few years. The market of TDDS is expected to reach USD 7.1 billion by 2023, from USD 5.7 …

Skin-targeted delivery of extracellular vesicle-encapsulated curcumin using dissolvable microneedle arrays

SS Yerneni, EP Yalcintas, JD Smith, S Averick… - Acta Biomaterialia, 2022 - Elsevier
Therapeutic benefits of curcumin for inflammatory diseases have been demonstrated.
However, curcumin's potential as a clinical therapeutic has been hindered due to its low …

Microneedles for efficient and precise drug delivery in cancer therapy

K Ganeson, AH Alias, V Murugaiyah, AAA Amirul… - Pharmaceutics, 2023 - mdpi.com
Cancer is the leading cause of death, acting as a global burden, severely impacting the
patients' quality of life and affecting the world economy despite the expansion of cumulative …

Engineered microneedle patches for controlled release of active compounds: recent advances in release profile tuning

R Jamaledin, P Makvandi, CKY Yiu… - Advanced …, 2020 - Wiley Online Library
Transdermal microneedle patches have attracted significant attention in the medical arena
over the last decade as alternatives to traditional drug delivery methods. Microneedle …

Engineered nasal dry powder for the encapsulation of bioactive compounds

A Baldelli, MA Boraey, H Oguzlu, A Cidem… - Drug Discovery …, 2022 - Elsevier
Highlights•Particle engineering can be used to design stable dry powder to be nasally
delivered;•Spray and spray freeze drying show the highest control over the properties of dry …

Diagnostic and drug release systems based on microneedle arrays in breast cancer therapy

S Khan, A Hasan, F Attar, MMN Babadaei… - Journal of Controlled …, 2021 - Elsevier
Microneedle arrays have recently received much attention as cancer detection and
treatment platforms, because invasive injections and detection of the biopsy are not needed …

Chitosan-based microneedle arrays for dermal delivery of Centella asiatica

C Ryall, S Chen, S Duarah, J Wen - International Journal of Pharmaceutics, 2022 - Elsevier
Centella asiatica, a medicinal herb used for wound healing, has a limited effect when
delivered as an ointment. Centella asiatica's active component asiatic acid (AA) increases …

An update on biomaterials as microneedle matrixes for biomedical applications

XP Zhang, YT He, WX Li, BZ Chen, CY Zhang… - Journal of Materials …, 2022 - pubs.rsc.org
Microneedles (MNs) have been developed for various applications such as drug delivery,
cosmetics, diagnosis, and biosensing. To meet the requirements of MNs used in these …

Microneedle-mediated transdermal nanodelivery systems: a review

S Ruan, Y Zhang, N Feng - Biomaterials Science, 2021 - pubs.rsc.org
The greatest limitation in the development of transdermal drug delivery systems is that only a
few drugs can permeate the skin due to the barrier function of the stratum corneum. Active …