Modifications in an emergency: the role of N1-methylpseudouridine in COVID-19 vaccines
The novel coronavirus SARS-CoV-2, the cause of the COVID-19 pandemic, has inspired
one of the most efficient vaccine development campaigns in human history. A key aspect of …
one of the most efficient vaccine development campaigns in human history. A key aspect of …
The mRNA vaccine revolution: COVID-19 has launched the future of vaccinology
During the COVID-19 pandemic, mRNA (mRNA) vaccines emerged as leading vaccine
candidates in a record time. Nonreplicating mRNA (NRM) and self-amplifying mRNA (SAM) …
candidates in a record time. Nonreplicating mRNA (NRM) and self-amplifying mRNA (SAM) …
[HTML][HTML] Detailed dissection and critical evaluation of the Pfizer/BioNTech and Moderna mRNA vaccines
X Xia - Vaccines, 2021 - mdpi.com
The design of Pfizer/BioNTech and Moderna mRNA vaccines involves many different types
of optimizations. Proper optimization of vaccine mRNA can reduce dosage required for each …
of optimizations. Proper optimization of vaccine mRNA can reduce dosage required for each …
[HTML][HTML] Engineering of the current nucleoside-modified mRNA-LNP vaccines against SARS-CoV-2
JT Granados-Riveron, G Aquino-Jarquin - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Currently, there are over 230 different COVID-19 vaccines under development around the
world. At least three decades of scientific development in RNA biology, immunology …
world. At least three decades of scientific development in RNA biology, immunology …
Vaccine mRNA can be detected in blood at 15 days post-vaccination
TE Fertig, L Chitoiu, DS Marta, VS Ionescu… - Biomedicines, 2022 - mdpi.com
COVID-19 mRNA vaccines effectively reduce incidence of severe disease, hospitalisation
and death. The biodistribution and pharmacokinetics of the mRNA-containing lipid …
and death. The biodistribution and pharmacokinetics of the mRNA-containing lipid …
N1-methylpseudouridine found within COVID-19 mRNA vaccines produces faithful protein products
Synthetic mRNA technology is a promising avenue for treating and preventing disease. Key
to the technology is the incorporation of modified nucleotides such as N1 …
to the technology is the incorporation of modified nucleotides such as N1 …
Computational design of mRNA vaccines
Abstract mRNA technology has emerged as a successful vaccine platform that offered a swift
response to the COVID-19 pandemic. Accumulating evidence shows that vaccine efficacy …
response to the COVID-19 pandemic. Accumulating evidence shows that vaccine efficacy …
Neutralizing activity and SARS-CoV-2 vaccine mRNA persistence in serum and breastmilk after BNT162b2 vaccination in lactating women
Background There is limited information on the functional neutralizing capabilities of
breastmilk SARS-CoV-2-specific antibodies and the potential adulteration of breastmilk with …
breastmilk SARS-CoV-2-specific antibodies and the potential adulteration of breastmilk with …
Cardiac side effects of RNA‐based SARS‐CoV‐2 vaccines: hidden cardiotoxic effects of mRNA‐1273 and BNT162b2 on ventricular myocyte function and structure
R Schreckenberg, N Woitasky, N Itani… - British Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose To protect against SARS‐CoV‐2 infection, the first mRNA‐
based vaccines, Spikevax (mRNA‐1273, Moderna) and Comirnaty (BNT162b2 …
based vaccines, Spikevax (mRNA‐1273, Moderna) and Comirnaty (BNT162b2 …
N1-methyl-pseudouridine is incorporated with higher fidelity than pseudouridine in synthetic RNAs
In vitro transcribed synthetic messenger RNAs (mRNAs) represent a novel therapeutic
modality. To overcome the inherent immunogenicity, as well as to increase the therapeutic …
modality. To overcome the inherent immunogenicity, as well as to increase the therapeutic …