How to increase cellular glutathione

D Giustarini, A Milzani, I Dalle-Donne, R Rossi - Antioxidants, 2023 - mdpi.com
Glutathione (GSH) has special antioxidant properties due to its high intracellular
concentration, ubiquity, and high reactivity towards electrophiles of the sulfhydryl group of its …

Assessment of glutathione/glutathione disulphide ratio and S-glutathionylated proteins in human blood, solid tissues, and cultured cells

D Giustarini, G Colombo, ML Garavaglia… - Free Radical Biology …, 2017 - Elsevier
Glutathione (GSH) is the major non-protein thiol in humans and other mammals, which is
present in millimolar concentrations within cells, but at much lower concentrations in the …

Curcumin attenuates hepatic mitochondrial dysfunction through the maintenance of thiol pool, inhibition of mtDNA damage, and stimulation of the mitochondrial …

J Zhang, K Bai, J He, Y Niu, Y Lu… - Journal of Animal …, 2018 - academic.oup.com
The aim of this study was to investigate the effects of dietary curcumin supplementation on
the performance, mitochondrial redox system, mitochondrial DNA (mtDNA) integrity, and …

Tuning the inflammatory response to silver nanoparticles via quercetin in Caco-2 (co-) cultures as model of the human intestinal mucosa

A Martirosyan, K Grintzalis, M Polet, L Laloux… - Toxicology letters, 2016 - Elsevier
Interaction of nanoparticles with food matrix components may cause unpredictable health
complications. Using an improved Caco-2 cell-based in vitro (co-) culture model the …

The effects of single and combined stressors on daphnids—enzyme markers of physiology and metabolomics validate the impact of pollution

A Michalaki, AR McGivern, G Poschet, M Büttner… - Toxics, 2022 - mdpi.com
The continuous global increase in population and consumption of resources due to human
activities has had a significant impact on the environment. Therefore, assessment of …

[HTML][HTML] Toxicity of “green solvents”-The impact of butyl methylimidazolium ionic liquids on daphnids

A Michalaki, D Kakavas, M Giannouli, K Grintzalis - Journal of Ionic Liquids, 2023 - Elsevier
Ionic liquids have been described as green solvents, however, their presence in the aquatic
environment may indicate a threat for key species. Focusing on the freshwater ecosystem …

Methods on LDL particle isolation, characterization, and component fractionation for the development of novel specific oxidized LDL status markers for atherosclerotic …

P Papadea, M Skipitari, E Kalaitzopoulou… - Frontiers in …, 2023 - frontiersin.org
The present study uses simple, innovative methods to isolate, characterize and fractionate
LDL in its main components for the study of specific oxidations on them that characterize …

Measurement of S-glutathionylated proteins by HPLC

D Giustarini, A Milzani, I Dalle-Donne, R Rossi - Amino Acids, 2022 - Springer
Abstract S-glutathionylated proteins (GSSP), ie, protein-mixed disulfides with glutathione
(GSH), are considered a suitable biomarker of oxidative stress. In fact, they occur within cells …

[HTML][HTML] Ageing differently: Sex-dependent ageing rates in Daphnia magna

J Constantinou, J Sullivan, L Mirbahai - Experimental Gerontology, 2019 - Elsevier
Ageing is defined as the gradual decline of normal physiological functions in a time-
dependent manner. Significant progress has been made in characterising the regulatory …

[HTML][HTML] Miniaturizing Nanotoxicity Assays in Daphnids

D Kakavas, K Panagiotidis, KD Rochfort, K Grintzalis - Animals, 2024 - mdpi.com
Simple Summary Applications of nanoparticles as well as their use have increased over the
past decades without sufficient research on their environmental impact. Focusing on …