Immunotoxins are proteins that contain a toxin along with an antibody or growth factor that
binds specifically to target cells. Nearly all protein toxins work by enzymatically inhibiting …

Recombinant immunotoxins are fusion proteins that contain the cytotoxic portion of a protein
toxin fused to the Fv portion of an antibody. The Fv binds to an antigen on a target cell and …

PURPOSE: To evaluate the toxicity, pharmacokinetics, immunogenicity, and antitumor
activity of anti-Tac (Fv)-PE38 (LMB-2), an anti-CD25 recombinant immunotoxin that contains …

Since the FDA approval of the first therapeutic antibody 35 years ago, antibody-based
products have gained prominence in the pharmaceutical market. Building on the early …

It was previously shown that amino acids 609-613 (REDLK) at the C-terminus of
Pseudomonas exotoxin (PE) are necessary for cytotoxicity, presumably by directing the toxin …

RNase T1 is the best known representative of a large family of ribonucleolytic proteins
secreted by fungi, mostly Aspergillus and Penicillium species. Ribotoxins stand out among …

Abstract CD25+ CD4+ T regulatory (Treg) cells regulate peripheral self tolerance and
possess the ability to suppress antitumor responses, which may in part explain the poor …

Immunotoxins constitute a new modality for the treatment of cancer, since they target cells
displaying specific surface-receptors or antigens. Immunotoxins contain a ligand such as a …

We report major responses in 4 of 4 patients with hairy cell leukemia (HCL) who have
recently been treated on a phase I trial with the recombinant immunotoxin LMB-2. The …

Immunotoxins are molecules that contain a protein toxin and a ligand that is either an
antibody or a growth factor. The ligand binds to a target cell antigen, and the target cell …