Vpr is a lentiviral accessory protein that is expressed late during the infection cycle and is
packaged in significant quantities into virus particles through a specific interaction with the …

Viruses often interfere with the DNA damage response to better replicate in their hosts. The
human immunodeficiency virus 1 (HIV-1) viral protein R (Vpr) protein has been reported to …

HIV replication in nondividing host cells occurs in the presence of high concentrations of
noncanonical dUTP, apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3 …

Hepatitis B virus (HBV) infection is a major public health problem. The high levels of HBV
DNA and HBsAg are positively associated with the development of secondary liver …

As intracellular parasites, viruses hijack the cellular machinery to facilitate their replication
and spread. This includes favouring the expression of their viral genes over host genes …

Evolutionarily conserved structure-selective endonuclease MUS81 forms a complex with
EME1 and further associates with another endonuclease SLX4-SLX1 to form a four-subunit …

There has been extraordinary progress in understanding the roles of lentiviral accessory
proteins in antagonizing host antiviral defense proteins. However, the precise primary …

The majority of T cells encountered by HIV-1 are non-activated and do not readily allow
productive infection. HIV-1 Vpr is highly abundant in progeny virions, and induces signalling …

The viral protein R (Vpr) is an accessory virulence factor of HIV-1 that facilitates infection in
immune cells. Cellular functions of Vpr are tied to its interaction with DCAF1, a substrate …

Vpr is a conserved primate lentiviral accessory protein that induces cell cycle arrest in G2.
The precise mechanism of this arrest and its benefit to viral replication is unknown. Here, we …