Pulmonary arterial hypertension (PAH) is a complex disease of multifactorial origin. While
registries have demonstrated that women are more susceptible to the disease, females with …

Significance: High-mobility group protein box 1 (HMGB1), a ubiquitous nuclear protein,
regulates chromatin structure and modulates the expression of many genes involved in the …

Objective A growing evidence demonstrates that inflammation is a major contributor to the
pathogenesis of pulmonary arterial hypertension (PAH). However, blocking inflammation …

The receptor for advanced glycation-end products (RAGE) is a multiligand receptor with a
role in inflammatory and pulmonary pathologies. Hyperactivation of RAGE by its ligands has …

Significance: Pulmonary arterial hypertension (PAH) is a progressive disease of the lung
vasculature characterized by the proliferation of all vascular wall cell types, including …

Objective: HIMF (hypoxia-induced mitogenic factor; also known as FIZZ1 [found in
inflammatory zone-1] or RELM [resistin-like molecule-α]) is an etiological factor of pulmonary …

Women are known to be associated with a higher susceptibility to pulmonary arterial
hypertension (PAH). In contrast, male PAH patients have a worse survival prognosis. In this …

The coronavirus SARS-CoV-2 of 2019 (COVID-19) causes a pandemic that has been
diagnosed in more than 70 million people worldwide. Mild-to-moderate COVID-19 …

Damage-associated molecular patterns, such as HMGB1 (high mobility group box 1), play a
well-recognized role in the development of pulmonary arterial hypertension (PAH), a …

Despite currently available therapies, cardiovascular diseases (CVD) are among the leading
causes of death globally. Biological sex is a critical determinant of the occurrence …