Numerous mutations in the Plasmodium falciparum Kelch13 (K13) protein confer resistance
to artemisinin derivatives, the current front-line antimalarial drugs. K13 is an essential …

Due to the high rate of transmissibility, Brazil became the new COVID-19 outbreak epicenter
and, since then, is being monitored to understand how SARS-CoV-2 mutates and spreads …

ABSTRACT RNA interference (RNAi)-mediated gene silencing can be used to control
specific insect pest populations. Unfortunately, the variable efficiency in the knockdown …

Terpene synthases are widely distributed among microorganisms and have been mainly
studied in members of the genus Streptomyces. However, little is known about the …

Measuring evolutionary rates at the residue level is indispensable for gaining structural and
functional insights into proteins. State-of-the-art tools for estimating rates take as input a …

Multiple sequence alignments (MSAs) are the workhorse of molecular evolution and
structural biology research. From MSAs, the amino acids that are tolerated at each site …

We introduce LEISR (Likehood Estimation of Individual Site Rates, pronounced “laser”), a
tool to infer relative evolutionary rates from protein and nucleotide data, implemented in …

Variation in mutation rates at sites in proteins can largely be understood by the constraint
that proteins must fold into stable structures. Models that calculate site‐specific rates based …

The relative evolutionary rates at individual sites in proteins are informative measures of
conservation or adaptation. Often used as evolutionarily aware conservation scores, relative …

Abstract Apolipoprotein A‐I (apoA‐I) has a key function in the reverse cholesterol transport.
However, aggregation of apoA‐I single point mutants can lead to hereditary amyloid …