Adult neurogenesis is one of the most drastic forms of brain plasticity in adulthood and there
is a growing body of evidence showing that, in the hippocampus, this process contributes to …

Neurodegenerative disorders are accompanied by neuronal degeneration and glial
dysfunction, resulting in cognitive, psychomotor, and behavioral impairment. Multiple factors …

Objective A decline in mitochondrial function and biogenesis as well as increased reactive
oxygen species (ROS) are important determinants of aging. With advancing age, there is a …

Mitochondrial dysfunction is central to the pathogenesis of neurological disorders. Neurons
rely on oxidative phosphorylation to meet their energy requirements and thus alterations in …

Epidemiological and clinical studies have long shown that exposure to high levels of heavy
metals are associated with increased risks of neurodegenerative diseases. It is widely …

Background The exchange of mitochondria reportedly plays an important role in cell–cell
communication in the central nervous system (CNS). The transfer of fragmented and …

Ageing is a crucial risk factor for Alzheimer's disease (AD) and is characterised by systemic
changes in both intracellular and extracellular microenvironments that affect the entire body …

The term type III diabetes (T3DM) has been proposed for Alzheimer's disease (AD) due to
the shared molecular and cellular features between type 2 diabetes (T2DM) and insulin …

Astrocytes can serve multiple functions in maintaining cellular homeostasis of the central
nervous system (CNS), and normal functions for autophagy in astrocytes is considered to …

Mitochondrial function has long been the focus of many therapeutic strategies for
ameliorating age-related neurodegeneration and cognitive decline. Historically, the role of …