Many factors must be considered and discussed with women when initiating a contraceptive
method and the risk of venous thromboembolism (VTE) is one of them. In this review, we …

The use of oral contraceptives (OC) is a well established risk factor for venous thrombosis. It
has been known for many years that almost all haemostatic parameters ie plasma levels of …

Background: Thrombin generation is a powerful tool to probe overall plasma coagulability.
Objective: To determine which plasma factors influence the various parameters of the …

Objective To compare the impact on thrombin generation of the new combined oral
contraceptive containing 15 mg estetrol and 3 mg drospirenone with ethinylestradiol (30 or …

We used the thrombin generation assay to evaluate the hypercoagulable state according to
JAK2 V617F mutational status in essential thrombocythemia (ET) and polycythemia vera …

Proteolytic inactivation of factors Va (FVa) and VIIIa (FVIIIa) by activated protein C (APC) and
its cofactors protein S and factor V (FV) is a key process in the physiological down …

There is currently no validated method to detect a prothrombotic phenotype. The question
remains, can tissue factor (TF) induced thrombin generation (TG), as measured with the …

Severe factor V (FV) deficiency is associated with mild to severe bleeding diathesis, but
many patients with FV levels lower than 1% bleed less than anticipated. We used calibrated …

Activated protein C resistance (APC-R) due to the single-nucleotide polymorphism factor V
Leiden (FVL) is the most common cause of hereditary thrombophilia. It is found …

Background Regulatory bodies recommend the use of an assay based on the assessment of
the endogenous thrombin potential (ETP) for the investigation of the activated protein C …