Global impact of proteoglycan science on human diseases
In this comprehensive review, we will dissect the impact of research on proteoglycans
focusing on recent developments involved in their synthesis, degradation, and interactions …
focusing on recent developments involved in their synthesis, degradation, and interactions …
Receptors and cofactors that contribute to SARS-CoV-2 entry: can skin be an alternative route of entry?
M Barthe, L Hertereau, N Lamghari… - International Journal of …, 2023 - mdpi.com
To prevent the spread of SARS-CoV-2, all routes of entry of the virus into the host must be
mapped. The skin is in contact with the external environment and thus may be an alternative …
mapped. The skin is in contact with the external environment and thus may be an alternative …
Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs
Although ACE2 is the primary receptor for Severe Acute Respiratory Syndrome Coronavirus
2 (SARS-CoV-2) infection, a systematic assessment of host factors that regulate binding to …
2 (SARS-CoV-2) infection, a systematic assessment of host factors that regulate binding to …
LRRC15 inhibits SARS-CoV-2 cellular entry in trans
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is mediated by
the entry receptor angiotensin-converting enzyme 2 (ACE2). Although attachment factors …
the entry receptor angiotensin-converting enzyme 2 (ACE2). Although attachment factors …
The elusive coreceptors for the SARS-CoV-2 spike protein
RL Berkowitz, DA Ostrov - Viruses, 2022 - mdpi.com
Evidence suggests that the N-terminal domain (NTD) of the SARS-CoV-2 spike protein
interacts with host coreceptors that participate in viral entry. Resolving the identity of …
interacts with host coreceptors that participate in viral entry. Resolving the identity of …
Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB–dependent IFITM3 expression
The innate immune system features a web of interacting pathways that require exquisite
regulation. To identify novel nodes in this immune landscape, we conducted a gain-of …
regulation. To identify novel nodes in this immune landscape, we conducted a gain-of …
Dissecting the Molecular Basis of Host Leucine-Rich Repeat Containing 15 Mediated Interaction with Receptor Binding Domain of SARS-CoV-2 Spike Protein: A …
The detection of leucine-rich repeat containing 15 (LRRC15) as a connecting link with
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the possibility …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the possibility …
Cell surface protein–protein interaction profiling for biological network analysis and novel target discovery
J Chen, M Fang, Y Li, H Ding, X Zhang, X Jiang… - Life …, 2024 - academic.oup.com
The secretome is composed of cell surface membrane proteins and extracellular secreted
proteins that are synthesized via secretory machinery, accounting for approximately one …
proteins that are synthesized via secretory machinery, accounting for approximately one …
LRRC15 suppresses SARS-CoV-2 infection and controls collagen production
Although ACE2 is the primary receptor for SARS-CoV-2 infection, a systematic assessment
of factors controlling SARS-CoV-2 host interactions has not been described. Here we used …
of factors controlling SARS-CoV-2 host interactions has not been described. Here we used …
[HTML][HTML] Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB
The innate immune system features a web of interacting pathways that require exquisite
regulation. To identify novel nodes in this immune landscape we conducted a gain of …
regulation. To identify novel nodes in this immune landscape we conducted a gain of …