Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions

Y Cho, S Jeong, H Kim, D Kang, J Lee… - … & molecular medicine, 2021 - nature.com
Osteoarthritis (OA) is the most common form of arthritis. It is characterized by progressive
destruction of articular cartilage and the development of chronic pain and constitutes a …

The role of matrix metalloproteinases in osteoarthritis pathogenesis: An updated review

ESE Mehana, AF Khafaga, SS El-Blehi - Life sciences, 2019 - Elsevier
Extensive degeneration of articular cartilage (AC) is a primary event in the pathogenesis of
osteoarthritis (OA) and other types of joint and bone inflammation. OA results in the loss of …

The rebirth of matrix metalloproteinase inhibitors: moving beyond the dogma

GB Fields - Cells, 2019 - mdpi.com
The pursuit of matrix metalloproteinase (MMP) inhibitors began in earnest over three
decades ago. Initial clinical trials were disappointing, resulting in a negative view of MMPs …

MMP13 is a critical target gene during the progression of osteoarthritis

M Wang, ER Sampson, H Jin, J Li, QH Ke, HJ Im… - Arthritis research & …, 2013 - Springer
Introduction Osteoarthritis (OA) is a degenerative joint disease affecting a large population of
people. The mechanism of this highly prevalent disease is not fully understood. Currently …

The potential role of synovial cells in the progression and treatment of osteoarthritis

Z Zou, H Li, K Yu, K Ma, Q Wang, J Tang, G Liu… - …, 2023 - Wiley Online Library
Osteoarthritis (OA), the commonest arthritis, is characterized by the progressive destruction
of cartilage, leading to disability. The Current early clinical treatment strategy for OA often …

[HTML][HTML] The OARSI histopathology initiative–recommendations for histological assessments of osteoarthritis in the rat

N Gerwin, AM Bendele, S Glasson… - Osteoarthritis and …, 2010 - Elsevier
OBJECTIVE: During the development of disease-modifying osteoarthritis (OA) drugs, rat
models of OA are frequently used for a first assessment of in vivo efficacy. The most …

[HTML][HTML] Matrix metalloproteinase collagenolysis in health and disease

S Amar, L Smith, GB Fields - … et Biophysica Acta (BBA)-Molecular Cell …, 2017 - Elsevier
The proteolytic processing of collagen (collagenolysis) is critical in development and
homeostasis, but also contributes to numerous pathologies. Mammalian interstitial …

Disease-modifying drugs in osteoarthritis: current understanding and future therapeutics

WM Oo, SPC Yu, MS Daniel… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: Osteoarthritis (OA) is a leading cause of pain and disability among adults with a
current prevalence of around 15% and a predicted prevalence of 35% in 2030 for …

[图书][B] The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis

J Bondeson, AB Blom, S Wainwright, C Hughes… - 2012 - academia.edu
Osteoarthritis (OA), one of the most common diseases among humans, is characterised
pathologically by focal areas of damage on articular cartilage centred on load-bearing …

Osteochondral alterations in osteoarthritis

S Suri, DA Walsh - Bone, 2012 - Elsevier
Osteoarthritis (OA) is a major cause of pain and disability in the aging population, but its
pathogenesis remains incompletely understood. Alterations beneath the articular cartilage at …