Glomerular endothelial cell (GEnC) fenestrations are a critical component of the glomerular
filtration barrier. Their unique nondiaphragmed structure is key to their function in glomerular …

Albumin is the most abundant plasma protein, exhibits extended circulating half-life, and its
properties have long been exploited for diagnostics and therapies. Many drugs intrinsically …

Tissue regeneration is limited in several organs, including the kidney, contributing to the
high prevalence of kidney disease globally. However, evolutionary and physiological …

Clonal expansion refers to the proliferation and selection of advantageous “clones” that are
better suited for survival in a Darwinian manner. In recent years, we have greatly enhanced …

Acute kidney injury (AKI) is an important risk factor for chronic kidney disease (CKD), but the
underlying mechanisms of failed tubule repair and AKI-CKD transition are incompletely …

Renal endothelial cells demonstrate an impressive remodeling potential during angiogenic
sprouting, vessel repair or while transitioning into mesenchymal cells. These different …

Adeno-associated virus (AAV) is a promising in vivo gene delivery platform showing
advantages in delivering therapeutic molecules to difficult or undruggable cells. However …

Background The vasoconstrictor effects of angiotensin II via type 1 angiotensin II receptors in
vascular smooth muscle cells are well established, but the direct effects of angiotensin II on …

Serial intravital 2-photon microscopy of the kidney and other abdominal organs is a powerful
technique to assess tissue function and structure simultaneously and over time. Thus, serial …

Intravital multiphoton microscopy has empowered investigators to study dynamic cell and
subcellular processes in vivo within normal and disease organs. Advances in hardware …