The endothelins comprise three structurally similar 21-amino acid peptides. Endothelin-1
and-2 activate two G-protein coupled receptors, ETA and ETB, with equal affinity, whereas …

Nirmatrelvir-ritonavir (NMVr) is used to treat symptomatic, nonhospitalized patients with
coronavirus disease-2019 (COVID-19) who are at high risk of progression to severe …

All three members of the endothelin (ET) family of peptides, ET-1, ET-2, and ET-3, are
expressed in the human kidney, with ET-1 being the predominant isoform. ET-1 and ET-2 …

This study examined the dose-response characteristics of aprocitentan, a dual endothelin
A/endothelin B receptor antagonist, in patients with essential hypertension. In a randomized …

Endothelin has emerged as a target for therapeutic intervention in systemic hypertension. As
a vasoconstrictor, comitogenic agent, linking pulse pressure and vascular remodeling, and …

Pulmonary arterial hypertension, a disease largely neglected until a few decades ago, is
presently the object of intense studies by several research teams. Despite considerable …

Pulmonary arterial hypertension (PAH) is a progressive disease of the lung vascular system,
which leads to right-sided heart failure and ultimately death if untreated. Treatments to …

Phenotypic switching of vascular smooth muscle cells (VSMCs) plays a key role in
atherosclerosis. Hyperhomocysteinemia (HHcy) is an independent risk factor for …

Macitentan (10 mg once daily orally), a dual endothelin receptor antagonist (ERA)
developed by modifying the structure of bosentan to increase the efficacity and safety, is …

The endothelin peptides bind to two receptors found on cells of vasculature and in tissues.
While the endothelin-A (ETA)-receptor is predominantly expressed in vascular smooth …