Background Antimicrobial resistance is a global health issue that requires immediate
attention in terms of new antibiotics and new antibiotic targets. The l-lysine biosynthesis …

There is an urgent need for new antibiotics given the rise of antibiotic resistance, and
succinyl-diaminopimelate desuccinylase (DapE, EC 3.5. 1.18) has emerged as a promising …

The microbial enzyme DapE plays a critical role in the lysine biosynthetic pathway and is
considered as a potentially safe antibiotic target. In this study, atomistic simulations are …

Peptidoglycan (PG) is an important bacterial macromolecule that confers cell shape and
structural integrity, and is a key antibiotic target. Its synthesis and turnover are carefully …

Growing antibiotic resistance by pathogenic bacteria has led to a global crisis. The bacterial
enzyme N-succinyl-l, l-diaminopimelic acid desuccinylase (DapE) provides a very attractive …

DapE is a Zn 2+-metallohydrolase recognized as a drug target for bacterial control. It is a
homodimer that requires the exchange of interface strands by an induced fit essential for …

Bacteria are becoming increasingly resistant to antibiotics, therefore there is an urgent need
for new classes of antibiotics to fight antibiotic resistance. Mammals do not express N ɑ …

Based on a hit from a high-throughput screen, a series of phenyltetrazole amides was
synthesized and assayed for inhibitory potency against DapE from Haemophilus influenzae …

Based on the inhibitory potencies from earlier reported tetrazole thioether analogs, we now
describe the synthesis and inhibition of pyrazole-based inhibitors of N-succinyl-l, l-2, 6 …

Peptidoglycan is an important bacterial macromolecule that confers cell shape and structural
integrity, and a key antibiotic target. The synthesis and turnover of peptidoglycan are …