Since first described by Paul Ehrlich in 1878, mast cells have been mostly viewed as
effectors of allergy. It has been only in the past two decades that mast cells have gained …

Asthma is a T lymphocyte–controlled disease of the airway wall caused by inflammation,
overproduction of mucus and airway wall remodeling leading to bronchial hyperreactivity …

Dendritic cells (DCs) are crucial for mounting allergic airway inflammation, but it is unclear
which subset of DCs performs this task. By using CD64 and MAR-1 staining, we reliably …

A standard goal of medicinal chemists has been to discover efficient and potent drug
candidates with specific enzyme-inhibitor abilities. In this regard, boron-based bioactive …

Abstract CD4+ T helper (TH) cells have crucial roles in orchestrating adaptive immune
responses. TH2 cells control immunity to extracellular parasites and all forms of allergic …

Whether epithelial cells play a role in triggering the immune cascade leading to T helper 2
(TH2)-type allergic inflammation is not known. We show here that human thymic stromal …

Dendritic cells (DCs) are central in the orchestration of the various forms of immunity and
tolerance. Their immunoregulatory role mainly relies on the ligation of specific receptors that …

Background IL-25 and IL-33 belong to distinct cytokine families, but experimental mouse
studies suggest their immunologic functions in type 2 immunity are almost entirely …

For many years, the interleukin-1 receptor family member ST2 was an orphan receptor that
was studied in the context of inflammatory and autoimmune disease. However, in 2005, a …

Asthma is a very complex and heterogeneous disease that is characterized by airway
inflammation and airway hyper-reactivity (AHR). The pathogenesis of asthma is associated …