Kallikrein-related peptidases (KLKs) are critical regulators of the tumour microenvironment.
KLKs are proteolytic enzymes regulating multiple functions of bioactive molecules including …

Cancer is a leading cause of mortality and morbidity worldwide. Around 90% of deaths are
caused by metastasis and just 10% by primary tumor. The advancement of treatment …

Three dimensional (3D) bioprinting of multiple cell types within optimised extracellular
matrices has the potential to more closely model the 3D environment of human physiology …

Motivation Due to the complexity and heterogeneity of multicellular biological systems,
mathematical models that take into account cell signalling, cell population behaviour and the …

Tumors are three-dimensional tissues where close contacts between cancer cells,
intercellular interactions between cancer and stromal cells, adhesion of cancer cells to the …

There is cumulating evidence that in vitro 3D tumor models with increased physiological
relevance can improve the predictive value of pre‐clinical research and ultimately contribute …

Techniques to provide in vitro tissue culture have undergone significant changes during the
last decades, and current applications involve interactions of cells and organoids, three …

For decades, 2D cell culture format on plastic has been the main workhorse in cancer
research. Though many important understandings of cancer cell biology were derived using …

Mathematical modeling has significant potential for understanding of biological models of
cancer and to accelerate the progress in cross-disciplinary approaches of cancer treatment …

Transcriptome profiling of 3D models compared to 2D models in various cancer cell lines
shows differential expression of TGF-β-mediated and cell adhesion pathways. Presence of …