Quercetin: An effective polyphenol in alleviating diabetes and diabetic complications

L Yan, M Vaghari-Tabari, F Malakoti… - Critical reviews in …, 2023 - Taylor & Francis
Various studies, especially in recent years, have shown that quercetin has beneficial
therapeutic effects in various human diseases, including diabetes. Quercetin has significant …

[HTML][HTML] Plants secondary metabolites as blood glucose-lowering molecules

MB Shehadeh, GARY Suaifan, AM Abu-Odeh - Molecules, 2021 - mdpi.com
Recently, significant advances in modern medicine and therapeutic agents have been
achieved. However, the search for effective antidiabetic drugs is continuous and …

Akt: A potential drug target for metabolic syndrome

R Miao, X Fang, J Wei, H Wu, X Wang… - Frontiers in Physiology, 2022 - frontiersin.org
The serine/threonine kinase Akt, also known as protein kinase B (PKB), is one of the key
factors regulating glucose and lipid energy metabolism, and is the core focus of current …

Mechanism involved in insulin resistance via accumulation of β-amyloid and neurofibrillary tangles: Link between type 2 diabetes and Alzheimer's disease

SK Rad, A Arya, H Karimian, P Madhavan… - Drug design …, 2018 - Taylor & Francis
The pathophysiological link between type 2 diabetes mellitus (T2DM) and Alzheimer's
disease (AD) has been suggested in several reports. Few findings suggest that T2DM has …

Plant-based antidiabetic nanoformulations: the emerging paradigm for effective therapy

S Dewanjee, P Chakraborty, B Mukherjee… - International journal of …, 2020 - mdpi.com
Diabetes mellitus is a life-threatening metabolic syndrome. Over the past few decades, the
incidence of diabetes has climbed exponentially. Several therapeutic approaches have …

A novel role of Nano selenium and sildenafil on streptozotocin-induced diabetic nephropathy in rats by modulation of inflammatory, oxidative, and apoptotic pathways

MF El-Azab, AA Al-Karmalawy, SA Antar, PA Hanna… - Life sciences, 2022 - Elsevier
Aims The present study aimed to investigate the effect of nano selenium, sildenafil, and their
combination on inflammation, oxidative stress, and apoptosis in streptozotocin-induced …

Oral nano drug delivery systems for the treatment of type 2 diabetes mellitus: an available administration strategy for antidiabetic phytocompounds

X Nie, Z Chen, L Pang, L Wang, H Jiang… - International journal …, 2020 - Taylor & Francis
In view of the worldwide serious health threat of type 2 diabetes mellitus (T2DM), natural
sources of chemotherapies have been corroborated as the promising alternatives, with the …

A review on phytochemical and pharmacological facets of tropical ethnomedicinal plants as reformed DPP-IV inhibitors to regulate incretin activity

S Chhabria, S Mathur, S Vadakan, DK Sahoo… - Frontiers in …, 2022 - frontiersin.org
Type 2 diabetes mellitus is a metabolic disorder resulting from impaired insulin secretion
and resistance. Dipeptidyl peptidase (DPP)-IV is an enzyme known to trigger the catalysis of …

[HTML][HTML] Molecular docking of phenolic compounds and screening of antioxidant and antidiabetic potential of Moringa oleifera ethanolic leaves extract from Qassim …

S Chigurupati, A Al-Murikhy, SA Almahmoud… - Saudi Journal of …, 2022 - Elsevier
Introduction Oxidative stress is crucial in diabetic pathophysiology, hence the prerequisite of
ingesting naturally derived antioxidants as a remedial target. This study investigates the …

Evaluation of in vivo antidiabetic, antidyslipidemic, and in vitro antioxidant activities of hydromethanolic root extract of Datura stramonium L. (Solanaceae)

YM Belayneh, Z Birhanu, EM Birru… - Journal of experimental …, 2019 - Taylor & Francis
Background The global morbidity and mortality rates of diabetes mellitus are persistently
increasing. There is a demand for new antidiabetic drugs because the safety and efficacy of …