During the past decade enormous advances have been made in our understanding of the
basic molecular machinery that is involved in the development of neuronal polarity. Far from …

Besides their well-established actions on reproductive functions, estrogens exert a variety of
actions on many regions of the nervous system that influence higher cognitive function, pain …

Cellular granules lacking boundary membranes harbor RNAs and their associated proteins
and play diverse roles controlling the timing and location of protein synthesis. Formation of …

Neurons, the basic information processing units of the nervous system, are characterized by
a complex polar morphology which is essential for their function. To attain their precise …

Genetic mutations of SHANK3 have been reported in patients with intellectual disability,
autism spectrum disorder (ASD) and schizophrenia. At the synapse, Shank3/ProSAP2 is a …

We used actin-perturbing agents and detergent extraction of primary hippocampal cultures
to test directly the role of the actin cytoskeleton in localizing GABAA receptors, AMPA-and …

Abstract Ca 2+/calmodulin-dependent protein kinase II (CaMKII) is a serine/threonine
protein kinase that regulates long-term potentiation and other forms of neuronal plasticity …

Dendritic spines are small protrusions that cover the surface of dendrites and bear the
postsynaptic component of excitatory synapses. Having an enlarged head connected to the …

Within dendritic spines, actin is presumed to anchor receptors in the postsynaptic density
and play numerous roles regulating synaptic transmission. However, the submicron …

Neurons transmit and receive information at specialized junctions called synapses.
Excitatory synapses form at the junction between a presynaptic axon terminal and a …