Considerable clinical and molecular variations have been known in retinal blinding
diseases in man and also in dogs. Different forms of retinal diseases occur in specific breed …

Retinitis pigmentosa (RP) is a heterogeneous group of inherited retinal disorders eventually
leading to blindness with different ages of onset, progression and severity. Human RP, first …

Centrosomes in animal cells are dynamic organelles with a proteinaceous matrix of
pericentriolar material assembled around a pair of centrioles. They organize the microtubule …

Joubert syndrome (JBTS) is a recessive neurodevelopmental ciliopathy characterized by a
pathognomonic hindbrain malformation. All known JBTS genes encode proteins involved in …

The primary cilium is a microtubule-based organelle that serves as a hub for many signaling
pathways. It functions as part of the centrosome or cilium complex, which also contains the …

Precise spatiotemporal control of microtubule nucleation and organization is critical for
faithful segregation of cytoplasmic and genetic material during cell division and signaling via …

Centriolar satellites are membrane-less structures that localize and move around the
centrosome and cilium complex in a microtubule-dependent manner. They play important …

Spontaneous canine models exist for several inherited retinal dystrophies. This review will
summarize the models and indicate where they have been used in translational gene …

The primary cilium is a microtubule‐based structure that protrudes from the cell surface in
diverse eukaryotic organisms. It functions as a key signaling center that decodes a variety of …

The primary cilium is a single immotile microtubule-based organelle that protrudes into the
extracellular space. Malformations and dysfunctions of the cilia have been associated with …