[HTML][HTML] Progress in the studies on the molecular mechanisms associated with multidrug resistance in cancers
L Zhang, B Ye, Z Chen, ZS Chen - Acta Pharmaceutica Sinica B, 2023 - Elsevier
Chemotherapy is one of the important methods to treat cancer, and the emergence of
multidrug resistance (MDR) is one major cause for the failure of cancer chemotherapy …
multidrug resistance (MDR) is one major cause for the failure of cancer chemotherapy …
Structure and function of hepatobiliary ATP binding cassette transporters
The liver is beyond any doubt the most important metabolic organ of the human body. This
function requires an intensive crosstalk within liver cellular structures, but also with other …
function requires an intensive crosstalk within liver cellular structures, but also with other …
ABC multidrug transporters: target for modulation of drug pharmacokinetics and drug-drug interactions
B Marquez, F Van Bambeke - Current drug targets, 2011 - ingentaconnect.com
Nine proteins of the ABC superfamily (P-glycoprotein, 7 MRPs and BCRP) are involved in
multidrug transport. Being localised at the surface of endothelial or epithelial cells, they …
multidrug transport. Being localised at the surface of endothelial or epithelial cells, they …
Computational approaches in cancer multidrug resistance research: Identification of potential biomarkers, drug targets and drug-target interactions
Like physics in the 19th century, biology and molecular biology in particular, has been
fertilized and enhanced like few other scientific fields, by the incorporation of mathematical …
fertilized and enhanced like few other scientific fields, by the incorporation of mathematical …
Multidrug Transport by the ABC Transporter Sav1866 from Staphylococcus aureus
S Velamakanni, Y Yao, DAP Gutmann… - Biochemistry, 2008 - ACS Publications
Sav1866 is an ATP-binding cassette (ABC) protein from the pathogen Staphylococcus
aureus and is a homologue of bacterial and human multidrug ABC transporters. Recently …
aureus and is a homologue of bacterial and human multidrug ABC transporters. Recently …
Overcoming bottlenecks in the membrane protein structural biology pipeline
D Hardy, RM Bill, A Jawhari… - Biochemical Society …, 2016 - portlandpress.com
Membrane proteins account for a third of the eukaryotic proteome, but are greatly under-
represented in the Protein Data Bank. Unfortunately, recent technological advances in X-ray …
represented in the Protein Data Bank. Unfortunately, recent technological advances in X-ray …
The molecular and physiological roles of ABCC6: more than meets the eye
O Le Saux, L Martin, Z Aherrahrou, G Leftheriotis… - Frontiers in …, 2012 - frontiersin.org
Abnormal mineralization occurs in the context of several common conditions, including
advanced age, diabetes, hypercholesterolemia, chronic renal failure, and certain genetic …
advanced age, diabetes, hypercholesterolemia, chronic renal failure, and certain genetic …
Localization of putative binding sites for cyclic guanosine monophosphate and the anti-cancer drug 5-fluoro-2′-deoxyuridine-5′-monophosphate on ABCC11 in …
Abstract Background The Multidrug Resistance Protein ABCC11/MRP8 is expressed in
physiological barriers and tumor breast tissues in which it secretes various substrates …
physiological barriers and tumor breast tissues in which it secretes various substrates …
Multidrug efflux pumps: The structures of prokaryotic ATP‐binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P …
One of the Holy Grails of ATP‐binding cassette transporter research is a structural
understanding of drug binding and transport in a eukaryotic multidrug resistance pump …
understanding of drug binding and transport in a eukaryotic multidrug resistance pump …
Discovery of novel multidrug resistance protein 4 (MRP4) inhibitors as active agents reducing resistance to anticancer drug 6-Mercaptopurine (6-MP) by structure and …
Multidrug resistance protein 4 (MRP4/ABCC4) is an ATP-binding cassette (ABC) transporter.
It is associated with multidrug resistance (MDR), which is becoming a growing challenge to …
It is associated with multidrug resistance (MDR), which is becoming a growing challenge to …