Epigenetic regulation of B cells and its role in autoimmune pathogenesis
B cells play a pivotal role in the pathogenesis of autoimmune diseases. Although previous
studies have shown many genetic polymorphisms associated with B-cell activation in …
studies have shown many genetic polymorphisms associated with B-cell activation in …
Histone H1 mutations in lymphoma: a link (er) between chromatin organization, developmental reprogramming, and cancer
Aberrant cell fate decisions due to transcriptional misregulation are central to malignant
transformation. Histones are the major constituents of chromatin, and mutations in histone …
transformation. Histones are the major constituents of chromatin, and mutations in histone …
An aged/autoimmune B-cell program defines the early transformation of extranodal lymphomas
L Venturutti, MA Rivas, BW Pelzer, R Flümann… - Cancer discovery, 2023 - AACR
A third of patients with diffuse large B-cell lymphoma (DLBCL) present with extranodal
dissemination, which is associated with inferior clinical outcomes. MYD88 L265P is a …
dissemination, which is associated with inferior clinical outcomes. MYD88 L265P is a …
T Cells Spatially Regulate B Cell Receptor Signaling in Lymphomas through H3K9me3 Modifications
LS Britto, D Balasubramani, S Desai… - Advanced …, 2024 - Wiley Online Library
Activated B cell‐like diffuse large B‐cell lymphoma (ABC‐DLBCL) is a subtype associated
with poor survival outcomes. Despite identifying therapeutic targets through molecular …
with poor survival outcomes. Despite identifying therapeutic targets through molecular …
[HTML][HTML] Pharmacologic Inhibition of the Histone Methyltransferase SETD2 with EZM0414 As a Novel Therapeutic Strategy in Relapsed or Refractory Multiple Myeloma …
J Totman, D Brach, V Motwani, S Howe, E Deutschman… - Blood, 2021 - Elsevier
Introduction: SETD2 is the only known histone methyltransferase (HMT) capable of
catalyzing H3K36 trimethylation (H3K36me3) in vivo. It plays an important role in several …
catalyzing H3K36 trimethylation (H3K36me3) in vivo. It plays an important role in several …
Un programma di invecchiamento/autoimmunità definisce la trasformazione precoce dei linfomi extranodali
G ANGI - thesis.unipd.it
Diffuse large B-cell lymphoma (DLBCL) is the most common and most aggressive type of
non-Hodgkin lymphoma (NHL) and originates from an aberrant germinal center (GC) …
non-Hodgkin lymphoma (NHL) and originates from an aberrant germinal center (GC) …