The plasminogen–activator plasmin system in physiological and pathophysiological angiogenesis
Angiogenesis is a process associated with the migration and proliferation of endothelial
cells (EC) to form new blood vessels. It is involved in various physiological and …
cells (EC) to form new blood vessels. It is involved in various physiological and …
The chemistry and biology of guanidine secondary metabolites
Covering: 2017–2019 Guanidine natural products isolated from microorganisms, marine
invertebrates and terrestrial plants, amphibians and spiders, represented by non-ribosomal …
invertebrates and terrestrial plants, amphibians and spiders, represented by non-ribosomal …
An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis
Increasing antimicrobial resistance compels the search for next-generation inhibitors with
differing or multiple molecular targets. In this regard, energy conservation in Mycobacterium …
differing or multiple molecular targets. In this regard, energy conservation in Mycobacterium …
The urokinase plasminogen activation system in pancreatic cancer: prospective diagnostic and therapeutic targets
Pancreatic cancer is a highly aggressive malignancy that features high recurrence rates and
the poorest prognosis of all solid cancers. The urokinase plasminogen activation system …
the poorest prognosis of all solid cancers. The urokinase plasminogen activation system …
Screening of 5-and 6-substituted amiloride libraries identifies dual-uPA/NHE1 active and single target-selective inhibitors
BJ Buckley, A Kumar, A Aboelela, RS Bujaroski… - International Journal of …, 2021 - mdpi.com
The K+-sparing diuretic amiloride shows off-target anti-cancer effects in multiple rodent
models. These effects arise from the inhibition of two distinct cancer targets: the trypsin-like …
models. These effects arise from the inhibition of two distinct cancer targets: the trypsin-like …
A tEMTing target? Clinical and experimental evidence for epithelial-mesenchymal transition in the progression of cutaneous squamous cell carcinoma (a scoping …
Cutaneous squamous cell carcinoma (cSCC) is a disease with globally rising incidence and
poor prognosis for patients with advanced or metastatic disease. Epithelial-mesenchymal …
poor prognosis for patients with advanced or metastatic disease. Epithelial-mesenchymal …
6-furopyridine hexamethylene amiloride is a non-selective P2X7 receptor antagonist
P Cuthbertson, A Elhage, D Al-Rifai, RA Sophocleous… - Biomolecules, 2022 - mdpi.com
P2X7 is an extracellular adenosine 5′-triphopshate (ATP)-gated cation channel present on
leukocytes, where its activation induces pro-inflammatory cytokine release and ectodomain …
leukocytes, where its activation induces pro-inflammatory cytokine release and ectodomain …
Roles of the Na+/H+ Exchanger Isoform 1 and Urokinase in Prostate Cancer Cell Migration and Invasion
Prostate cancer is a leading cause of cancer-associated deaths in men over 60 years of age.
Most patients are killed by tumor metastasis. Recent evidence has implicated a role of the …
Most patients are killed by tumor metastasis. Recent evidence has implicated a role of the …
Systematic evaluation of structure–property relationships and pharmacokinetics in 6-(hetero) aryl-substituted matched pair analogs of amiloride and 5-(N, N …
BJ Buckley, A Aboelela, H Majed, RS Bujaroski… - Bioorganic & Medicinal …, 2021 - Elsevier
The K+-sparing diuretic amiloride elicits anticancer activities in multiple animal models.
During our recent medicinal chemistry campaign aiming to identify amiloride analogs with …
During our recent medicinal chemistry campaign aiming to identify amiloride analogs with …
A dual-targeting succinate dehydrogenase and F1Fo-ATP synthase inhibitor rapidly sterilizes replicating and non-replicating Mycobacterium tuberculosis
Mycobacterial bioenergetics is a validated target space for antitubercular drug development.
Here, we identify BB2-50F, a 6-substituted 5-(N, N-hexamethylene) amiloride derivative as a …
Here, we identify BB2-50F, a 6-substituted 5-(N, N-hexamethylene) amiloride derivative as a …