Genomic analysis has greatly influenced the diagnosis and clinical management of patients
affected by diverse forms of hematologic malignancies. Here, we review how genetic …

Multiple endocrine neoplasia (MEN) refers to a group of autosomal dominant disorders with
generally high penetrance that lead to the development of a wide spectrum of endocrine and …

Disease overview Hairy cell leukemia (HCL) and HCL-like disorders, including HCL variant
(HCL-V) and splenic diffuse red pulp lymphoma (SDRPL), are a very heterogeneous group …

Acute promyelocytic leukemia (APL) is a subtype of myeloid leukemia characterized by
differentiation block at the promyelocyte stage. Besides the presence of chromosomal …

Recent data suggest an increase in the overall incidence of parathyroid disorders, with
primary hyperparathyroidism (PHPT) being the most prevalent parathyroid disorder. PHPT is …

Classical hairy cell leukemia (cHCL) is characterized by a near 100% frequency of the BRAF
V600E mutation, whereas∼ 30% of variant HCLs (vHCLs) have MAP2K1 mutations …

The activating mutation of the BRAF serine/threonine protein kinase (BRAF V600E) is the
key driver mutation in hairy cell leukemia (HCL), suggesting opportunities for therapeutic …

Hairy cell leukemia (HCL) is a distinct clinicopathological entity whose underlying genetic
lesion has remained a mystery for over half a century. The BRAF V600E mutation is now …

In contrast to other solid tumors within the abdominal cavity, epithelial ovarian cancers
(EOCs) tend to undergo peritoneal metastasis. Thus, the peritoneal immune …

Precise regulation of chromatin architecture is vital to physiological processes including
hematopoiesis. ARID1A is a core component of the mammalian SWI/SNF complex, which is …