Glycogen synthase kinase-3 inhibitors: preclinical and clinical focus on CNS-A decade onward

SM Arciniegas Ruiz, H Eldar-Finkelman - Frontiers in molecular …, 2022 - frontiersin.org
The protein kinase, GSK-3, participates in diverse biological processes and is now
recognized a promising drug discovery target in treating multiple pathological conditions …

Mechanisms and therapeutic implications of GSK-3 in treating neurodegeneration

I Rippin, H Eldar-Finkelman - Cells, 2021 - mdpi.com
Neurodegenerative disorders are spreading worldwide and are one of the greatest threats to
public health. There is currently no adequate therapy for these disorders, and therefore there …

Reduced inhibitory and excitatory input onto parvalbumin interneurons mediated by perineuronal net might contribute to cognitive impairments in a mouse model of …

L Zhang, YZ Gao, CJ Zhao, JY Xia, JJ Yang, MH Ji - Neuropharmacology, 2023 - Elsevier
Sepsis-associated encephalopathy (SAE) is commonly defined as diffuse brain dysfunction
and can manifest as delirium to coma. Accumulating evidence has suggested that …

Theta and gamma oscillatory dynamics in mouse models of Alzheimer's disease: A path to prospective therapeutic intervention

SF Mehak, AB Shivakumar, S Kumari… - Neuroscience & …, 2022 - Elsevier
Understanding the neural basis of cognitive deficits, a key feature of Alzheimer's disease
(AD), is imperative for achieving the therapy of the disease. Rhythmic oscillatory activities in …

DNA methylation and the opposing NMDAR dysfunction in schizophrenia and major depression disorders: a converging model for the therapeutic effects of …

LT Flynn, WJ Gao - Molecular psychiatry, 2023 - nature.com
Psychedelic compounds are being increasingly explored as a potential therapeutic option
for treating several psychiatric conditions, despite relatively little being known about their …

Mouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show EEG abnormalities in common with schizophrenia patients

LE Herzog, L Wang, E Yu, S Choi, Z Farsi… - Translational …, 2023 - nature.com
Schizophrenia is a heterogeneous psychiatric disorder with a strong genetic basis, whose
etiology and pathophysiology remain poorly understood. Exome sequencing studies have …

[HTML][HTML] Phenotypic analysis of multielectrode array EEG biomarkers in developing and adult male Fmr1 KO mice

CR Jonak, SA Assad, TA Garcia, MS Sandhu… - Neurobiology of …, 2024 - Elsevier
Abstract Fragile X Syndrome (FXS) is a leading known genetic cause of intellectual disability
with symptoms that include increased anxiety and social and sensory processing deficits …

Ketamine as a pharmacological tool for the preclinical study of memory deficit in schizophrenia

JES Santiago, GR Roldán, O Picazo - Behavioural Pharmacology, 2023 - journals.lww.com
Schizophrenia is a serious neuropsychiatric disorder characterized by the presence of
positive symptoms (hallucinations, delusions, and disorganization of thought and language) …

5-HT2A receptor dysregulation in a schizophrenia relevant mouse model of NMDA receptor hypofunction

K Nakao, M Singh, K Sapkota, A Fitzgerald… - Translational …, 2022 - nature.com
Blockade of N-methyl-D-aspartate receptors (NMDAR) is known to augment cortical
serotonin 2A receptors (5-HT2ARs), which is implicated in psychosis. However, the …

Glycogen synthase kinase-3: a focal point for advancing pathogenic inflammation in depression

RT McCallum, ML Perreault - Cells, 2021 - mdpi.com
Increasing evidence indicates that the host immune response has a monumental role in the
etiology of major depressive disorder (MDD), motivating the development of the …