Advances in carbohydrate chemistry have certainly made common oligosaccharides much
more accessible. However, many current methods still rely heavily upon specialized …

Sialic acids are cytoprotectors, mainly localized on the surface of cell membranes with
multiple and outstanding cell biological functions. The history of their structural analysis …

Glycosyltransferases catalyze glycosidic bond formation using sugar donors containing a
nucleoside phosphate or a lipid phosphate leaving group. Only two structural folds, GT-A …

Oligosaccharides together with oligonucleotides and oligopeptides comprise the three major
classes of natural biopolymers. Automated systems for oligonucleotide and oligopeptide …

Sialic acids are a subset of nonulosonic acids, which are nine-carbon α-keto aldonic acids.
Natural existing sialic acid-containing structures are presented in different sialic acid forms …

Glycosylation reactions mainly catalyzed by glycosyltransferases (Gts) occur almost
everywhere in the biosphere, and always play crucial roles in vital processes. In order to …

Site-specific modification of proteins is a major challenge in modern chemical biology due to
the large number of reactive functional groups typically present in polypeptides. Because of …

Pasteurella multocida was first shown to be the causative agent of fowl cholera by Louis
Pasteur in 1881. Since then, this Gram-negative bacterium has been identified as the …

The important roles played by human milk oligosaccharides (HMOS), the third major
component of human milk, in the health of breast-fed infants have been increasingly …

Sialic acids are a family of negatively charged monosaccharides which are commonly
presented as the terminal residues in glycans of the glycoconjugates on eukaryotic cell …