Influenza A viruses (IAVs) are respiratory pathogens that cause severe morbidity and
mortality worldwide. They affect cellular processes such as proliferation, protein synthesis …

Acute viral infections are characterized by rapid increases in viral load, leading to cellular
damage and the resulting induction of complex innate and adaptive antiviral immune …

Vaccines have had broad medical impact, but existing vaccine technologies and production
methods are limited in their ability to respond rapidly to evolving and emerging pathogens …

Primary tumors may create the premetastatic niche in secondary organs for subsequent
metastasis. Humoral immunity contributes to the progression of certain cancers, but the roles …

Deciphering immune recognition is critical for understanding a broad range of diseases and
for the development of effective vaccines and immunotherapies. Efforts to do so are limited …

Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract infections in
infants and is characterized by pulmonary infiltration of B cells in fatal cases. We analyzed …

Memories of previous immune events enable barrier tissues to rapidly recall distinct
environmental exposures. To effectively inform future responses, these past experiences …

Cytokine-based therapies for cancer have not achieved widespread clinical success
because of inherent toxicities. Treatment for pancreatic cancer is limited by the dense stroma …

B cells have long been regarded as simple antibody production units, but are now becoming
known as key players in both adaptive and innate immune responses. However, several …

CD 4 T cells convey a number of discrete functions to protective immunity to influenza, a
complexity that distinguishes this arm of adaptive immunity from B cells and CD 8 T cells …