Tumoroids, a valid preclinical screening platform for monitoring cancer angiogenesis

Z Abbasi-Malati, P Khanicheragh, MT Narmi… - Stem Cell Research & …, 2024 - Springer
In recent years, biologists and clinicians have witnessed prominent advances in in vitro 3D
culture techniques related to biomimetic human/animal tissue analogs. Numerous data have …

Replacement in angiogenesis research: Studying mechanisms of blood vessel development by animal-free in vitro, in vivo and in silico approaches

MW Laschke, Y Gu, MD Menger - Frontiers in physiology, 2022 - frontiersin.org
Angiogenesis, the development of new blood vessels from pre-existing ones, is an essential
process determining numerous physiological and pathological conditions. Accordingly …

Development of a combined lipid-based nanoparticle formulation for enhanced siRNA delivery to vascular endothelial cells

Y He, D Bi, JA Plantinga, G Molema, J Bussmann… - Pharmaceutics, 2022 - mdpi.com
Low transfection efficiency in endothelial cells (EC) is still a bottleneck for the majority of
siRNA-based vascular delivery approaches. In this work, we developed a lipid-based …

The Inhibitory Effect of Selected D2 Dopaminergic Receptor Agonists on VEGF-Dependent Neovascularization in Zebrafish Larvae: Potential New Therapy in …

N Kasica, A Święch, K Saładziak, J Mackiewicz… - Cells, 2022 - mdpi.com
Pathological angiogenesis is correlated with many ophthalmic diseases. The most common
are exudative age-related macular degeneration and proliferative diabetic retinopathy. The …

Chronotropic and vasoactive properties of the gut bacterial short-chain fatty acids in larval zebrafish

H Sree Kumar, AS Wisner, IT Schiefer… - Physiological …, 2024 - journals.physiology.org
Short-chain fatty acids (SCFAs) produced by the gut bacteria have been associated with
cardiovascular dysfunction in humans and rodents. However, studies exploring effects of …

Chronotropic and vasoactive properties of the gut 2 bacterial short chain fatty acids in larval zebrafish 3

HS Kumar, AS Wisner, IT Schiefer… - Physiological …, 2024 - journals.physiology.org
Short-chain fatty acids (SCFAs) by the gut bacteria have been associated with
cardiovascular dysfunction 18 in humans and rodents. However, studies exploring effects of …

Moderate Elevation of Homocysteine Induces Endothelial Dysfunction through Adaptive UPR Activation and Metabolic Rewiring

B Chatterjee, F Fatima, S Seth, S Sinha Roy - Cells, 2024 - mdpi.com
Elevation of the intermediate amino acid metabolite Homocysteine (Hcy) causes
Hyperhomocysteinemia (HHcy), a metabolic disorder frequently associated with mutations in …

Acute exposure of Isopyrazam damages the developed cardiovascular system of zebrafish (Danio rerio)

Y Yan, S Liang, T Zhang, C Deng, H Li… - … Science and Health …, 2023 - Taylor & Francis
Isopyrazam (IPZ) is one of the broad-spectrum succinate dehydrogenase inhibitor fungicides
(SDHIs). Although the potential bio-toxicity of SDHIs has been reported hourly, the specific …

Alk1/Endoglin dependent increases in vein endothelial cell sizes precipitate arteriovenous malformations

Z Diwan, AF Siekmann - bioRxiv, 2023 - biorxiv.org
Aberrations in blood vessel diameters can disrupt the hierarchical patterning of the
vasculature and cause congenital vascular anomalies, such as arteriovenous malformations …

Analysis of Vascular Morphogenesis in Zebrafish

M Hubert, W Herzog - Cell Migration in Three Dimensions, 2023 - Springer
Abstract Analysis of cardiovascular development in zebrafish embryos has become a major
driver of vascular research in recent years. Imaging-based analyses have allowed the …