Functional genomics of lactic acid bacteria: from food to health

FP Douillard, WM De Vos - Microbial cell factories, 2014 - Springer
Genome analysis using next generation sequencing technologies has revolutionized the
characterization of lactic acid bacteria and complete genomes of all major groups are now …

Aerobic respiration metabolism in lactic acid bacteria and uses in biotechnology

MB Pedersen, P Gaudu, D Lechardeur… - Annual Review of …, 2012 - annualreviews.org
The lactic acid bacteria (LAB) are essential for food fermentations and their impact on gut
physiology and health is under active exploration. In addition to their well-studied …

PePPER: a webserver for prediction of prokaryote promoter elements and regulons

A de Jong, H Pietersma, M Cordes, OP Kuipers, J Kok - BMC genomics, 2012 - Springer
Background Accurate prediction of DNA motifs that are targets of RNA polymerases, sigma
factors and transcription factors (TFs) in prokaryotes is a difficult mission mainly due to as yet …

Control of glutamate homeostasis in Bacillus subtilis: a complex interplay between ammonium assimilation, glutamate biosynthesis and degradation

K Gunka, FM Commichau - Molecular microbiology, 2012 - Wiley Online Library
Glutamate, the major amino group donor in anabolism, is synthesized by the combined
action of the glutamine synthetase (GS) and the glutamate synthase (GOGAT) in Bacillus …

Common patterns–unique features: nitrogen metabolism and regulation in Gram-positive bacteria

J Amon, F Titgemeyer… - FEMS microbiology …, 2010 - academic.oup.com
Gram-positive bacteria have developed elaborate mechanisms to control ammonium
assimilation, at the levels of both transcription and enzyme activity. In this review, the …

The Evolution of gene regulation research in Lactococcus lactis

J Kok, LA van Gijtenbeek, A de Jong… - FEMS microbiology …, 2017 - academic.oup.com
Lactococcus lactis is a major microbe. This lactic acid bacterium (LAB) is used worldwide in
the production of safe, healthy, tasteful and nutritious milk fermentation products. Its huge …

Protein costs do not explain evolution of metabolic strategies and regulation of ribosomal content: does protein investment explain an anaerobic bacterial C rabtree …

A Goel, TH Eckhardt, P Puri, A de Jong… - Molecular …, 2015 - Wiley Online Library
Protein investment costs are considered a major driver for the choice of alternative metabolic
strategies. We tested this premise in L actococcus lactis, a bacterium that exhibits a distinct …

Genome-scale modeling and transcriptome analysis of Leuconostoc mesenteroides unravel the redox governed metabolic states in obligate heterofermentative lactic …

L Koduru, Y Kim, J Bang, M Lakshmanan, NS Han… - Scientific reports, 2017 - nature.com
Obligate heterofermentative lactic acid bacteria (LAB) are well-known for their beneficial
health effects in humans. To delineate the incompletely characterized metabolism that …

Impact of glutamine transporters on pneumococcal fitness under infection-related conditions

T Härtel, M Klein, U Koedel, M Rohde… - Infection and …, 2011 - Am Soc Microbiol
The genomic analysis of Streptococcus pneumoniae predicted six putative glutamine uptake
systems, which are expressed under in vitro conditions, as shown here by reverse …

Glutamine synthetase and GlnR regulate nitrogen metabolism in Paenibacillus polymyxa WLY78

X Zhao, Y Song, T Wang, C Hua, R Hu… - Applied and …, 2023 - Am Soc Microbiol
Paenibacillus polymyxa WLY78, a N2-fixing bacterium, has great potential use as a
biofertilizer in agriculture. Recently, we have revealed that GlnR positively and negatively …